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Displaying results 5021 - 5030 of 10000 in total
  1. Drug

    Fluorofuranylnorprogesterone F-18

    go.drugbank.com/drugs/DB15282
    Investigational

    Fluorofuranylnorprogesterone F-18 is under investigation in clinical trial NCT02455453 (Assessment of Functional Status of Estrogen Receptors in Breast Cancer by Positron Emission Tomography).

    Synonyms: 19-NORPREGN-4-ENE-3,20-DIONE, 21-(FLUORO-18F)-16,17-((R)-(2-FURANYLMETHYLENE)BIS(OXY))-, (16.ALPHA.)-, FFNP F-18
  2. Drug

    Arsenic trioxide

    go.drugbank.com/drugs/DB01169
    ApprovedInvestigational

    In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. … The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: LEUSENOX 2 MG/ML IV İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 10 ADET, TRISENOX 1 MG/1 ML IV INFÜZYON IÇIN KONSANTRE ÇÖZELTI IÇEREN AMPUL, 10 ADET
  3. Drug

    Esomeprazole

    go.drugbank.com/drugs/DB00736
    ApprovedInvestigational

    [A177577, A177580] Due to their good safety profile and as several PPIs are available over the counter without a prescription, their current use in North America is widespread. … Esomeprazole is the s-isomer of [DB00338], which is a racemate of the S- and R-enantiomer.

    Mixtures: OCAM PROTECT ® 15 MG TABLETAS DE LIBERACION RETARDADA, OCAM PROTECT® 7.5 TABLETAS DE LIBERACIÓN RETARDADACategories: 2-Pyridinylmethylsulfinylbenzimidazoles, Heterocyclic Compounds, 2-Ring
  4. Drug

    Dimethylaminomicheliolide

    go.drugbank.com/drugs/DB17111
    Investigational

    Synonyms: AZULENO(4,5-B)FURAN-2(3H)-ONE, 3-((DIMETHYLAMINO)METHYL)-3A,4,5,7,8,9,9A,9B-OCTAHYDRO-9-HYDROXY-6,9-DIMETHYL-, (3R,3AS,9R,9AS,9BS)-Categories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Alfacalcidol

    go.drugbank.com/drugs/DB01436
    ApprovedInvestigationalNutraceutical

    Alfacalcidol, or 1-alpha-hydroxycholecalciferol or 1-alpha-hydroxyvitamin D3, is a non-endogenous analogue of [vitamin D]. … vitamin D resistant rickets and osteomalacia.

    Synonyms: 1-hydroxycholecalciferol, (5Z,7E)-9,10-seco-5,7,10(19)-cholestatrien-1α,3β-diolCategories: Vitamin D and Analogues
  6. Drug

    Loratadine

    go.drugbank.com/drugs/DB00455
    ApprovedInvestigational

    Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. … [A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.

    Mixtures: Clarinase 5 mg/ 120 mg Retardtabletten, LORATADINA+ PSEUDOEFEDRINA0.5 MG + 6 MG/ML SOLUCION PEDIATRICACategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  7. Drug

    Glimepiride

    go.drugbank.com/drugs/DB00222
    ApprovedInvestigational

    2 diabetes mellitus. … First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control.

    Mixtures: METGLITAL LEX 850 MG / 2 MG TABLETAS DE LIBERACION PROLONGADA, METGLITAL LEX 850 MG / 2 MG TABLETAS DE LIBERACION PROLONGADACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates
  8. Drug

    Sodium chloride

    go.drugbank.com/drugs/DB09153
    ApprovedInvestigationalVet approved

    Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions.

    Mixtures: CLORURO DE POTASIO 20 MEQ/L. CLORURO DE SODIO 40 MEQ/L EN DEXTROSA AL 5% X 250 ML, CLORURO DE POTASIO 20 MEQ/L. CLORURO DE SODIO 40 MEQ/L. EN DEXTROSA 5%Products: CLORURO DE SODIO DE 2 MEQ/ML SOLUCIÓN INYECTABLE, CLORURO DE SODIO 9 MG / ML
  9. Drug

    Docetaxel

    go.drugbank.com/drugs/DB01248
    ApprovedInvestigational

    Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. … [A259676,L46466] Docetaxel reversibly binds to microtubulin with high affinity in a 1:1 stoichiometric ratio, allowing it to prevent cell division and promote to cell death.

    Synonyms: N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxelCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  10. Drug

    Benzatropine

    go.drugbank.com/drugs/DB00245
    ApprovedInvestigational

    It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. … The generation of structure-activity relationships proved that benztropine derivatives with the presence of a chlorine substituent in the para position in one of the phenyl rings produces an increased

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesSynonyms: benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether, 3α-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane