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Displaying results 5061 - 5070 of 10000 in total
  1. Drug

    Belzutifan

    go.drugbank.com/drugs/DB15463
    ApprovedInvestigational

    [L35995] The HIF-2α protein was first identified in the 1990s by researchers at UT Southwestern Medical Center as a key player in the growth of certain cancers. … Belzutifan is an inhibitor of hypoxia-inducible factor 2α (HIF-2α) used in the treatment of von Hippel-Lindau (VHL) disease-associated cancers.

    Categories: MATE 2 Inhibitors, Cytochrome P-450 Substrates
  2. Drug

    Sotorasib

    go.drugbank.com/drugs/DB15569
    ApprovedInvestigational

    [A187547] Sotorasib was granted FDA approval on May 28, 2021,[L34288] followed by the European Commission's approval on January 6, 2022.[L56070] … Sotorasib, also known as AMG-510, is an acrylamide-derived KRAS inhibitor developed by Amgen.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-(1M)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2- methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one, Kras G12C inhibitor 9
  3. Drug

    Cedazuridine

    go.drugbank.com/drugs/DB15694
    ApprovedInvestigational

    Astex Pharmaceuticals Inc under the name INQOVI®. … Myelodysplastic syndromes (MDS) are a group of hematopoietic neoplasms that give rise to variable cytopenias progressing to secondary acute myeloid leukemia (sAML), which is invariably fatal if untreated

    Categories: Heterocyclic Compounds, 1-RingSynonyms: (4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine
  4. Drug

    Amfenac

    go.drugbank.com/drugs/DB15911
    Investigational

    Amfenac is an arylacetic acid derivative and a non0steroidal anti-inflammatory agent.[A275203, A275208]

    Synonyms: (2-Amino-3-benzoylphenyl)acetic acid
  5. Drug

    Menadione bisulfite

    go.drugbank.com/drugs/DB15944
    Investigational

    Mixtures: HEMOSIN K, HEMOSIN-KCategories: Vitamin K
  6. Drug

    Strychnine

    go.drugbank.com/drugs/DB15954
    Experimental

    Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household setting
  7. Drug

    Homochlorcyclizine

    go.drugbank.com/drugs/DB15979
    Investigational

    Categories: Cytochrome P-450 CYP2D6 Inhibitors, Heterocyclic Compounds, 1-Ring
  8. Drug

    Indocyanine green

    go.drugbank.com/drugs/DB16024
    ApprovedInvestigationalWithdrawn

    Categories: Heterocyclic Compounds, 2-Ring, Compounds used in a research, industrial, or household setting
  9. Drug

    Plixorafenib

    go.drugbank.com/drugs/DB16038
    Investigational

    PLX8394 is under investigation in clinical trial NCT02428712 (A Study of PLX8394 as a Single Agent in Patients With Advanced Unresectable Solid Tumors).

  10. Drug

    Nemiralisib

    go.drugbank.com/drugs/DB16253
    Investigational

    Nemiralisib is under investigation in clinical trial NCT03345407 (Dose Finding Study of Nemiralisib (GSK2269557) in Subjects With an Acute Moderate or Severe Exacerbation of Chronic Obstructive Pulmonary

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring