This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Indocyanine green is a diagnostic agent for vascular imagine and radiography of the eye, as well as liver function tests.
- Generic Name
- Indocyanine green
- DrugBank Accession Number
- DB16024
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Experimental
- Structure
Structure for Indocyanine green (DB16024)
- Weight
- Average: 774.97
Monoisotopic: 774.27732387 - Chemical Formula
- C43H47N2NaO6S2
- Synonyms
- Indocyanine green
- External IDs
- 222-751-5
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- ATC Codes
- V04CX01 — Indocyanine green
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as naphthalenes. These are compounds containing a naphthalene moiety, which consists of two fused benzene rings.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Naphthalenes
- Sub Class
- Not Available
- Direct Parent
- Naphthalenes
- Alternative Parents
- 3-alkylindoles / Tertiary alkylarylamines / Sulfonyls / Organosulfonic acids / Alkanesulfonic acids / Propargyl-type 1,3-dipolar organic compounds / Enamines / Azacyclic compounds / Organopnictogen compounds / Organic zwitterions show 3 more
- Substituents
- 3-alkylindole / Alkanesulfonic acid / Amine / Aromatic heteropolycyclic compound / Azacycle / Enamine / Hydrocarbon derivative / Indole or derivatives / Naphthalene / Organic 1,3-dipolar compound show 18 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- cyanine dye, 1,1-diunsubstituted alkanesulfonate, benzoindole (CHEBI:31696)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- 3599-32-4
- InChI Key
- MOFVSTNWEDAEEK-UHFFFAOYSA-M
- InChI
- InChI=1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1
- IUPAC Name
- sodium 2-{7-[1,1-dimethyl-3-(4-sulfonatobutyl)-1H,2H,3H-benzo[e]indol-2-ylidene]hepta-1,3,5-trien-1-yl}-1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indol-3-ium
- SMILES
- [Na+].CC1(C)C(=CC=CC=CC=CC2=[N+](CCCCS([O-])(=O)=O)C3=CC=C4C=CC=CC4=C3C2(C)C)N(CCCCS([O-])(=O)=O)C2=CC=C3C=CC=CC3=C12
References
- General References
- FDA Thailand: Diagnogreen (Indocyanine Green) Injection [Link]
- External Links
- ChemSpider
- 18108
- 5775
- ChEMBL
- CHEMBL1646
- Wikipedia
- Indocyanine_green
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Diagnostic Cirrhosis of the Liver 1 4 Completed Other Graves' Disease / Thyroid Cancer / Thyroid Goiter 1 4 Completed Treatment Laparoscopic Cholecystectomy 1 4 Completed Treatment Metastatic Bone Sarcomas / Metastatic Ewing Sarcoma / Non-Rhabdo. Soft Tissue Sarcoma / Pediatric Renal Tumor / Pulmonary Metastasis / Rhabdomyosarcomas 1 4 Enrolling by Invitation Diagnostic Lymphedema 1 4 Not Yet Recruiting Treatment Erectile Dysfunction Following Radical Prostatectomy / Prostate Cancer Adenocarcinoma 1 4 Recruiting Diagnostic Gastric Cancer 1 4 Recruiting Prevention Acute Cholecystitis / Bile Duct Injury 1 4 Recruiting Prevention Gastric Ulcer / Obesity, Morbid 1 4 Recruiting Treatment Lymph Node Metastases / Prostate Cancer 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 6.05 Chemaxon pKa (Strongest Acidic) -0.94 Chemaxon pKa (Strongest Basic) 4.85 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 120.65 Å2 Chemaxon Rotatable Bond Count 14 Chemaxon Refractivity 228.88 m3·mol-1 Chemaxon Polarizability 86.08 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at December 14, 2020 18:13 / Updated at December 06, 2023 04:54