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Bicuculline
go.drugbank.com/drugs/DB11562ExperimentalIt was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.
Abdavomeran
go.drugbank.com/drugs/DB15695Investigational[L15007, L15012] Early results from a phase 1/2 study in 45 healthy adult volunteers demonstrated RBD-binding immunoglobulin levels and 50% serum neutralizing titers higher than those observed in [COVID … BNT162b1 is one of four advanced mRNA-based vaccines being developed through "Project Lightspeed," a joint program between Pfizer and BioNTech.
Categories: Amino Acids, Peptides, and ProteinsPPI-2458
go.drugbank.com/drugs/DB05864Investigationalsuch as cancer and rheumatoid arthritis. … Clinical development with previous fumagillin derivatives has been limited by their toxicity profile.
Categories: Amino Acids, Peptides, and ProteinsImidazole-4-carboxylic acid
go.drugbank.com/drugs/DB16194ExperimentalImidazole-4-carboxylic acid is under investigation in clinical trial NCT00583895 (Safety and Efficacy Study of Imcooh Cream in Patients Suffering From Moderate Atopic Dermatitis).
Regramostim
go.drugbank.com/drugs/DB05386InvestigationalRegramostim (GM-CSF) is a differentially glycosylated factor produced mainly by activated T cells and macrophages. … GM-CSF stimulates proliferation, activation and differentiation of macrophages and granulocytes and their progenitors.
Categories: Amino Acids, Peptides, and Proteins, Intercellular Signaling Peptides and ProteinsGabexate
go.drugbank.com/drugs/DB12831InvestigationalGabexate has been investigated for use in cancer, ischemia-reperfusion injury, and pancreatitis.[A19218,A19219,A19220] … Gabexate is a synthetic serine protease inhibitor which has been used as an anticoagulant. It also known to decrease production of inflammatory cytokines.
Adecatumumab
go.drugbank.com/drugs/DB05006InvestigationalEpCAM (CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, pancreatic and lung cancer.
Categories: Amino Acids, Peptides, and ProteinsPicolinic acid
go.drugbank.com/drugs/DB05483ExperimentalIt acts as an anti-infective and immunomodulator and is produced in approximately 25-50 mg quantities by the body on a daily basis through the breakdown of tryptophan. … As a therapeutic agent, the molecule works by binding to zinc finger proteins (ZFPs) in a way that changes their structures and disrupts zinc binding, inhibiting function.
Plitidepsin
go.drugbank.com/drugs/DB04977InvestigationalAplidine is a peptide found in tunicates which shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers. The specific marine organism is _Aplidium albicans_.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsBOS172722
go.drugbank.com/drugs/DB15498Investigational[A187120] An in vivo study combined BOS172722 with [Paclitaxel] for the treatment of triple hormone receptor negative breast cancer, and demonstrated promising synergistic effects.[A187123] … [A187123] Normally, Mps1 supports the proper division of cancer cells, ensuring survival and replication.