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humanized SMART Anti-IL-12 Antibody
go.drugbank.com/drugs/DB05848ExperimentalSMART Anti-IL-12 Antibody was humanized at PDL from a murine anti-IL-12 antibody that was licensed, together with certain intellectual property related to anti-IL-12 therapy, from Hoffmann-La Roche Inc … The humanized anti-IL-12 antibody is an important addition to PDL's already strong pipeline of humanized antibodies being developed for the treatment of autoimmune diseases.
Ensifentrine
go.drugbank.com/drugs/DB16157ApprovedInvestigational[L50903] It works to induce bronchodilator and reduce inflammation in COPD.[A263913] … Ensifentrine is a first-in-class, selective dual inhibitor of the phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) enzymes.
Cyclic GMP
go.drugbank.com/drugs/DB02315ExperimentalIts levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed) … It is a cellular regulatory agent and has been described as a second messenger.
Categories: Nucleic Acids, Nucleotides, and NucleosidesTosylchloramide
go.drugbank.com/drugs/DB14708InvestigationalTosylchloramide, also known as chloramine-T, is a chlorinated and deprotonated sulfonamide used as a mild disinfectant. It is not stable in the water dissolved form.
Categories: Indicators and Reagents, Antiseptics and DisinfectantsTunicamycin
go.drugbank.com/drugs/DB13172ExperimentalIt is used as an experimental tool to induce unfolded protein response. Tunicamycin is produced by Streptomyces clavuligerus and Streptomyces lysosuperficus bacteria along with several other species. … One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first
Categories: Nucleic Acids, Nucleotides, and NucleosidesBenactyzine
go.drugbank.com/drugs/DB09023ApprovedWithdrawnBenactyzine is an anticholinergic drug used as an antidepressant in the treatment of depression and associated anxiety. … It does not possess any antihistamine properties.
Lucinactant
go.drugbank.com/drugs/DB04897ApprovedIt also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). … It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P).
Categories: Amino Acids, Peptides, and ProteinsPerospirone
go.drugbank.com/drugs/DB08922InvestigationalIt is commonly present as the hydrated hydrochloride salt form. … Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors.
Dexamethasone acetate
go.drugbank.com/drugs/DB14649ApprovedInvestigationalVet approved[A188724] Dexamethasone acetate has largely been replaced by [dexamethasone] phosphate and continues to be administered for a large variety of inflammatory conditions. … one-fifth and one-third in patients on oxygen therapy and mechanical ventilation, respectively.
Ditiocarb
go.drugbank.com/drugs/DB02520InvestigationalA chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM.