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Displaying results 511 - 520 of 3730 in total
  1. Target

    Interleukin-21 receptor

    go.drugbank.com/bio_entities/BE0010657
    TargetHumans

    This is a receptor for interleukin-21

    Polypeptides: Interleukin-21 receptorSynonyms: IL-21 receptor, Novel interleukin receptor
  2. Target

    Neuromedin-B receptor

    go.drugbank.com/bio_entities/BE0013104
    TargetHumans

    Receptor for neuromedin-B (PubMed:1655761). … Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)

    Polypeptides: Neuromedin-B receptorSynonyms: Neuromedin-B-preferring bombesin receptor
  3. Target

    Interleukin-23 receptor

    go.drugbank.com/bio_entities/BE0015564
    TargetHumans

    Associates with IL12RB1 to form the interleukin-23 receptor.

    Polypeptides: Interleukin-23 receptorSynonyms: IL-23 receptor
  4. Target

    Discoidin domain receptor

    go.drugbank.com/bio_entities/BE0027487
    TargetHumans

    Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. … It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation.

    Polypeptides: Discoidin domain-containing receptor 2, Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin domain receptor 2, Discoidin receptor tyrosine kinase
  5. Target

    Interleukin-2 receptor

    go.drugbank.com/bio_entities/BE0027978
    TargetHumans

    Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. … Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

    Polypeptides: Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit alphaSynonyms: IL-2 receptor subunit gamma, IL-2 receptor subunit alpha
  6. Drug

    Pretomanid

    go.drugbank.com/drugs/DB05154
    ApprovedInvestigational

    Research in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy regimens.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  7. Drug

    Fondaparinux

    go.drugbank.com/drugs/DB00569
    ApprovedInvestigational

    knee surgery); to prevent VTE in patients undergoing abdominal surgery who are are at high risk of thromboembolic complications; in the treatment of deep vein thrombosis (DVT) and pumonary embolism (PE

  8. Target

    Cannabinoid receptor 1

    go.drugbank.com/bio_entities/BE0000061
    TargetHumans

    G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such

    Polypeptides: Cannabinoid receptor 1Function: cannabinoid receptor activity
  9. Target

    Cannabinoid receptor 2

    go.drugbank.com/bio_entities/BE0000095
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase.

    Polypeptides: Cannabinoid receptor 2Function: cannabinoid receptor activity
  10. Target

    Substance-P receptor

    go.drugbank.com/bio_entities/BE0000384
    TargetHumans

    Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. … Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity)

    Polypeptides: Substance-P receptorSynonyms: NK-1 receptor, Tachykinin receptor 1