Cannabinoid receptor 1

BE0000061ProteinHumansCNR1

G protein-coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723, PubMed:27768894, PubMed:27851727, PubMed:35637350). It is acted on by 33 drugs in DrugBank.

Gene name
CNR1
UniProtKB entry
P21554Swiss-Prot
Cellular location
Cell membrane
Residues / weight
472 residues · 52,857 Da
Also known as
CANN6 · CB-R · CB1 · CNR

Resolves to

Protein
UniProtP21554UniProt nameCNR1_HUMAN
Gene
HGNCHGNC:2159NCBI Gene1268GenBank29915GeneCardsCNR1
Pharmacology
IUPHAR/GtoPdb56KEGGhsa:1268
Structure
PDB1LVQPDB1LVRPDB2B0Y
Drugs

What you can answer from here — as of September 07, 2019

33DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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94+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cannabinoid receptor 1, how selective are they, and which programs against it are still in active trials?

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