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Displaying results 5221 - 5230 of 8010 in total
  1. Drug

    TAK-754

    go.drugbank.com/drugs/DB17850
    Investigational

    Developed by Takeda, it is being investigated for the treatment of hemophilia A.[A259831]

  2. Drug

    Ligelizumab

    go.drugbank.com/drugs/DB11856
    Investigational

    Initial trials of ligelizumab suggest a greater efficacy over its predecessor for the treatment of CSU.[A242367] … [A242292] Ligelizumab is currently under investigation for the treatment of chronic spontaneous urticaria (CSU), an autoimmune-driven inflammatory condition.

  3. Drug

    Dilmapimod

    go.drugbank.com/drugs/DB12140
    Investigational

    Previous p38 MAP-kinase inhibitors have been hindered in development by liver toxicity. Methotrexate (common treatment for RA patients) also has potential liver toxicity.}

  4. Drug

    CXD101

    go.drugbank.com/drugs/DB16182
    Investigational

    CXD101 is under investigation in clinical trial NCT03873025 (A Study of CXD101 in Combination With Pembrolizumab for Relapsed or Refractory Diffuse Large B-cell Lymphoma).

  5. Drug

    Lanoteplase

    go.drugbank.com/drugs/DB06245
    Experimental

  6. Drug

    Lomifylline

    go.drugbank.com/drugs/DB18002
    Approved

    Categories: Drugs for Obstructive Airway Diseases
  7. Drug

    AVR118

    go.drugbank.com/drugs/DB04979
    Investigational

    of cancers); for its ability to stimulate the immune system to attack tumor cells (especially those cancer cells that have been damaged by chemotherapeutic agents) and for its ability to treat cachexia … AVR118 is being studied for the promise shown in its ability to mitigate the toxic side effects of other drugs (including those used to treat HIV infection and chemotherapeutic drugs employed in the treatment

  8. Drug

    Q-Derp1

    go.drugbank.com/drugs/DB05857
    Experimental

    Q-Derp1 is developed by Cytos Biotechnology as an immunodrug. It is an antigen for the prevention of various major chronic diseases. Derp1 is the dominant allergic protein found in dust mite feces.

  9. Drug

    Perfluorodecalin

    go.drugbank.com/drugs/DB16292
    Investigational

    is under investigation in clinical trial NCT03668665 (Influencing Wound Healing Through the Application of Hyaluronic Acid With Perfluorodecalin and Physalis Angulata Extract After Split Skin Removal From

  10. Pathway

    mTOR Signaling pathway

    smpdb.ca/view/SMP0535455
    Signaling

    Cellular energy status is sensed by AMPK, which upon activation by a high AMP/ATP ratio phosphorylates TSC2 and the mTORC1 subunit Raptor to inhibit mTORC1, whereas high ATP from glycolysis suppresses … Amino acids signal through distinct routes: Leucine binds to CASTOR1 to dissociate it from GATOR2, blocking GATOR1 and enabling RagA/B‑GTP loading to recruit mTORC1 to lysosomes; Arginine is sensed by

    Drugs: Arginine · L-Glutamine · Leucine · ATP · Magnesium cation · Zinc
    Enzymes: Cytosolic arginine sensor for mTORC1 subunit 1