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Displaying results 5241 - 5250 of 10000 in total
  1. Drug

    Gabexate

    go.drugbank.com/drugs/DB12831
    Investigational

    Gabexate is a synthetic serine protease inhibitor which has been used as an anticoagulant. It also known to decrease production of inflammatory cytokines. … Gabexate has been investigated for use in cancer, ischemia-reperfusion injury, and pancreatitis.[A19218,A19219,A19220]

  2. Drug

    Siplizumab

    go.drugbank.com/drugs/DB06371
    Investigational

  3. Drug

    Lercanidipine

    go.drugbank.com/drugs/DB00528
    ApprovedInvestigationalWithdrawn

    Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.

    Categories: Angiotensin II receptor blockers (ARBs) and calcium channel blockers
  4. Target

    T-lymphocyte activation antigen CD86

    go.drugbank.com/bio_entities/BE0000846
    TargetHumans

    Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:11279501) … Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:

    Synonyms: CTLA-4 counter-receptor B7.2
  5. Target

    Integrin beta-1

    go.drugbank.com/bio_entities/BE0003575
    TargetHumans

    May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. … Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.

    Synonyms: Fibronectin receptor subunit beta
  6. Target

    Serine/threonine-protein kinase TNNI3K

    go.drugbank.com/bio_entities/BE0009401
    TargetHumans

    May play a role in cardiac physiology

    Synonyms: Cardiac ankyrin repeat kinase
  7. Drug

    HGS-TR2J

    go.drugbank.com/drugs/DB05895
    Experimental

    HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies. … It is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial.

  8. Drug

    Senazodan

    go.drugbank.com/drugs/DB19879
    Experimental

    Senazodan is a small molecule drug. The usage of the INN stem '-dan' in the name indicates that Senazodan is a cardiac stimulant, pimobendan derivative.

  9. Drug

    Adibendan

    go.drugbank.com/drugs/DB20623
    Experimental

    Adibendan is a small molecule drug. The usage of the INN stem '-dan' in the name indicates that Adibendan is a cardiac stimulant, pimobendan derivative.

  10. Drug

    R112

    go.drugbank.com/drugs/DB06252
    Experimental

    R112 is an investigational compound developed to treat Allergic Rhinitis. It's mechanism of action is to inhibit SYK kinase.