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Oleoyl-estrone
go.drugbank.com/drugs/DB04870InvestigationalBody protein loss is an unpleasant effect of fat loss by the restriction of calories, and studies show that this drug appears to avoid this effect. … This hormone occurs naturally and is found circulating in various animal species and humans.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsClomocycline
go.drugbank.com/drugs/DB00453ExperimentalClomocycline is a tetracycline used to treat bacterial infections.
Distigmine
go.drugbank.com/drugs/DB13694InvestigationalIt improves detrusor function thereby restoring normal voiding patterns in patients suffering from detrusor underactivity [A27176]. … It is an anticholinergic drug and long-acting reversible carbamate cholinesterase inhibitor that binds directly and competitively to the agonist binding sites of muscurinic receptors.
Volixibat
go.drugbank.com/drugs/DB13914InvestigationalAccording to Shire, the pharmaceutical manufacturer of Volixibat, it has been granted fast track status by the Food and Drug Administration due to promising initial results and a need for therapeutic treatments … Also known as the ileal bile acid transporter (IBAT), ASBT is primarily responsible for the enterohepatic recirculation of bile acids and ultimately for hepatic lipid and glucose metabolism [A32120].
Biomodulin T
go.drugbank.com/drugs/DB16529ExperimentalBiomodulin T is a polypeptide fraction from bovine thymus with immunomodulatory effects.
Prasterone sulfate
go.drugbank.com/drugs/DB05804InvestigationalDHEA-S is the principal adrenal androgen and is secreted together with cortisol under the control of ACTH and prolactin. DHEA-S is elevated with hyperprolactinemia.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsNerandomilast
go.drugbank.com/drugs/DB18237ApprovedInvestigational[L54141] Nerandomilast exerts both anti-fibrotic and immunomodulatory effects as PDE4 inhibition elevates intracellular cAMP levels and reduces the expression of pro-fibrotic growth factors and inflammatory … It has one chiral center and is the R-stereoisomer.[L54126] On October 7, 2025, nerandomilast was approved as the first new treatment for idiopathic pulmonary fibrosis in more than a decade.
Levosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. … It also relaxes vascular smooth muscle by opening adenosine triphosphate sensitive potassium channels. Levosimendan is used to manage acutely decompensated congestive heart failure.
Polysorbate 20
go.drugbank.com/drugs/DB11178ApprovedIt is also an excipient that stabilizes emulsions and suspensions in pharmaceutical products and lubricant in ophthalmic solutions. … Polysorbate 20 is a wetting agent in food products, as well as washing agent, stabilizer and solubilizer in labratory assays and industrial applications.