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Efmoroctocog alfa
go.drugbank.com/drugs/DB11607ApprovedInvestigationalFactor VIII is a blood coagulant factor involved in the intrinsic pathway to form fibrin, or a blood clot. … The B domain of factor VIII is deleted. In animal models of haemophilia, efmoroctocog alfa demonstrated an approximately two-fold longer t½ than commercially available rFVIII products [A31551].
Products: ELOCTATE® 250 UI, ELOCTATE® 500 UIFactor XIII (human)
go.drugbank.com/drugs/DB12909ApprovedInvestigationalAs the half-life of endogenous Factor XIII is long (5-11 days), prophylactic therapy with the replacement of FXIII can be given every 4-6 to maintain hemostasis[A32363]. … Within the body, FXIII circulates as a heterotetramer composed of 2 A-subunits and 2 B-subunits (A2B2)[A32363].
International brands: Fibrogammin PProducts: Fibrogammin 250 IE Pulver und Lösungsmittel zur Herstellung einer Injektions-/Infusionslösung, Corifact 250Pilocarpine
go.drugbank.com/drugs/DB01085ApprovedInvestigationalA naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist. … [A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors.
Mixtures: Timpilo 2, E-pilo-2 Oph SolnCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 InhibitorsMethyldopa
go.drugbank.com/drugs/DB00968ApprovedInvestigationalMethyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading to the inhibition of adrenergic neuronal outflow and reduction of vasoconstrictor adrenergic signals. … [A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form.
Synonyms: α-methyl-L-dopa, 3-Hydroxy-alpha-methyl-L-tyrosineInternational brands: Nu-MedopaTerlipressin
go.drugbank.com/drugs/DB02638ApprovedInvestigationalTerlipressin is a synthetic analogue of vasopressin, which is an endogenous neurohormone that acts as a vasoconstrictor.[A2601] It is a prodrug of [lypressin], or lysine vasopressin. … [L43217] As a potent vasopressor, terlipressin has been investigated in various shock states and conditions with diminished vasomotor tone.
Products: GLYPRESSIN 1 MG/8,5 ML IV ENJEKSIYONLUK COZELTI ICEREN AMPUL, 5 ADET, Glycylpressin 1 mg - Pulver und Lösungsmittel zur Herstellung einer InjektionslösungBismuth subsalicylate
go.drugbank.com/drugs/DB01294ApprovedVet approved[A230728] It is an active ingredient found in Pepto-Bismol, a common over-the-counter medication that is used to temporarily treat discomforts of the stomach and gastrointestinal tract. … [L32318] Bismuth subsalicylate is a component of HELIDAC Therapy (bismuth subsalicylate, [metronidazole], and [tetracycline]), which is a treatment regimen indicated for the eradication of _H. pylori_
Synonyms: 2-Hydroxy-benzo[1,3,2]dioxabismin-4-oneProducts: Up and Up 5-symptom Digestive Relief, Stomach Relief, 24-7 LifeSalicylic acid
go.drugbank.com/drugs/DB00936ApprovedInvestigationalVet approvedA compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions.
Mixtures: Actikerall 5 mg/g + 100 mg/g Lösung zur Anwendung auf der Haut, REPARİL-GEL N %1 + %5 JEL, 50 GCategories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesFremanezumab
go.drugbank.com/drugs/DB14041ApprovedInvestigationalFremanezumab is a humanized monoclonal antibody targeted against human calcitonin gene-related peptide (CGRP) for the prevention of migraine headaches. … [L11779] Along with other recently approved anti-CGRP therapies such as [galcanezumab], [erenumab], and the oral CGRP antagonist [ubrogepant], fremanezumab represents an important step forward in the treatment
Products: AJOVY SOLUTION FOR INJECTION IN PRE-FILLED PEN 225 MG/1.5ML, AJOVY SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE 225 MG/1.5MLFlucloxacillin
go.drugbank.com/drugs/DB00301ApprovedInvestigationalWithdrawnAntibiotic analog of cloxacillin.
Synonyms: (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillinCategories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesOctocrylene
go.drugbank.com/drugs/DB09535ApprovedWhat makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. … Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties.
Mixtures: Olay Professional ProX Clear UV Moisturizer SPF 15, Olay ProX Clear Moisturizer Broad Spectrum SPF 15Products: Panama Jack SPF 4, Panama Jack SPF 4 Dark Tanning Oil