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Sepofarsen
go.drugbank.com/drugs/DB16327InvestigationalSepofarsen is under investigation in clinical trial NCT03913143 (A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)).
Cardiolipin Biosynthesis CL(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:5(5Z,8Z,11Z,14Z,17Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))
smpdb.ca/view/SMP0252842MetabolicCardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition. It is essential for the optimal function of numerous enzymes that are involved in mitochondrial...
Vanzacaftor
go.drugbank.com/drugs/DB18373ApprovedInvestigational[L52275,A179677] Vanzacaftor was first approved by the US FDA in December 2024 in combination with another CFTR corrector - [tezacaftor], which binds to a different site than vanzacaftor - and [deutivacaftor
Acylcarnitine (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoylcarnitine
smpdb.ca/view/SMP0123486Metabolic(9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoyl-CoA reacts with L-carnitine to form (9S,10E,12Z)-9-hydroperoxyoctadeca-10,12-dienoylcarnitine.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAcylcarnitine (4Z,10Z,12E)-3-Hydroxytetradeca-4,10,12-trienoylcarnitine
smpdb.ca/view/SMP0124206Metabolic(4Z,10Z,12E)-3-Hydroxytetradeca-4,10,12-trienoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (4Z,10Z,12E)-3-hydroxytetradeca-4,10,12-trienoyl-CoA reacts with L-carnitine to form (4Z,10Z,12E)-3-hydroxytetradeca-4,10,12-trienoylcarnitine.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAcylcarnitine (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoylcarnitine
smpdb.ca/view/SMP0124340Metabolic(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoyl-CoA reacts with L-carnitine to form (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoylcarnitine.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreDe Novo Triacylglycerol Biosynthesis TG(14:0/22:5(4Z,7Z,10Z,13Z,16Z)/22:5(4Z,7Z,10Z,13Z,16Z))
smpdb.ca/view/SMP0016754MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(15:0/22:5(4Z,7Z,10Z,13Z,16Z)/22:5(7Z,10Z,13Z,16Z,19Z))
smpdb.ca/view/SMP0017456MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(15:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:4(7Z,10Z,13Z,16Z))
smpdb.ca/view/SMP0017606MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(16:0/22:4(7Z,10Z,13Z,16Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))
smpdb.ca/view/SMP0018069MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...