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Levosimendan
go.drugbank.com/drugs/DB00922ApprovedInvestigationalWithdrawnLevosimendan increases calcium sensitivity to myocytes by binding to troponin C in a calcium dependent manner. This increases contractility without raising calcium levels. … Levosimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
Categories: Compounds used in a research, industrial, or household settingProducts: SIMDAX 2.5 MG/ML CONCENTRATE FOR SOLUTION FOR INFUSION, Simdax 2.5 mg/ml concentrate for solution for infusion.Irinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigationalIrinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree _Camptotheca acuminate_. … [A263381] As an anticancer drug, irinotecan was first commercially available in Japan in 1994 to treat various cancers such as lung, cervical and ovarian cancer.
Categories: Topoisomerase I InhibitorsProducts: IRITEC CONCENTRATE FOR SOLUTION FOR INFUSION 40mg/2ml, IRITEC CONCENTRATE FOR SOLUTION FOR INFUSION 100mg/5mlDocusate
go.drugbank.com/drugs/DB11089ApprovedHowever the effectiveness of docusate in treating constipation remains unclear, as several studies report docusate to be no more effective than placebo for increasing the frequency of stool or stool softening … Docusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201].
Mixtures: Prenatal Vitamin No 53 Iron Fum Folic Acid Docusate CA DHA, 2 In 1laxative Stool Softener and Stiulant LaxativeCategories: Drugs for ConstipationDrotaverine
go.drugbank.com/drugs/DB06751ApprovedWithdrawn[A231619] Drotaverine is not approved by the FDA, European Medicines Agency, or Health Canada. It is approved for use in Thailand as oral tablets or intramuscular injections.[L22689] … [A231619] It is a benzylisoquinoline derivative that is structurally related to [papaverine], although it displays more potent antispasmodic activities than papaverine.
Categories: Drugs for Functional Gastrointestinal DisordersInternational brands: No-SpaAluminum sesquichlorohydrate
go.drugbank.com/drugs/DB11108ApprovedAluminum sesquichlorohydrate is an aluminum salt used as an antiperspirant agent, cosmetic astringent and deodorant agent. It works by physically blocking eccrine sweat gland ducts [A31171].
Mixtures: Lactovit DEODORANT ROLL-ON MEN INVISIBLE, Lactovit Mens Roll On Antiperspirant DeodorantProducts: ESIKA VALERUS FOR MEN Roll-On, ESIKA VEHEMENCE FOR MEN Roll-OnDesmopressin
go.drugbank.com/drugs/DB00035ApprovedInvestigationalIt is considered a first-line therapy for central diabetes insipidus but is ineffective in patients with nephrogenic diabetes insipidus, where the kidneys are non-responsive to the hormone [A275458, L56105 … On January 15, 2026, the FDA approved a new low-dose sublingual film formulation specifically for the treatment of nocturia in patients at high risk for fluid overload, utilizing a specialized delivery
Products: MINIRIN Oral Lyophilisate for sublingual 60mcg, MINIRIN Oral Lyophilisate for sublingual 120mcgAntithymocyte immunoglobulin (rabbit)
go.drugbank.com/drugs/DB00098ApprovedInvestigationalThymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. … Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
Synonyms: r-ATGProducts: Thymoglobuline 5mg/ml Powder for concentrate for solution for infusion, THYMOGLOBULİNE 5 MG-ML IV İNFÜZYON İÇİN LİYOFİLİZE TOZ İÇEREN FLAKONLevetiracetam
go.drugbank.com/drugs/DB01202ApprovedInvestigationalIt was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs). … make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.
Products: Levetiracetam in Sodium Chloride, 6-URIdarubicin
go.drugbank.com/drugs/DB01177ApprovedInvestigationalAn orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Categories: Topoisomerase II InhibitorsProducts: ZAVEDOS FOR INJECTION 5 mg/vial, ZAVEDOS FOR INJECTION 10 mg/vialPembrolizumab
go.drugbank.com/drugs/DB09037ApprovedInvestigational[L38934,L43257] In September 2025, the US FDA approved a formulation of pembrolizumab that includes [berahyaluronidase alfa] (Keytruda QLEX) to allow for subcutaneous administration.[L54026] … [F136] It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014,[L2954] becoming the first approved therapy against PD-1.
Products: KEYTRUDA SOLUTION FOR INFUSION 25MG/ML, Keytruda 100mg Solution for Infusion