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4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
go.drugbank.com/drugs/DB04632ExperimentalSynonyms: 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDEArimoclomol
go.drugbank.com/drugs/DB05025ApprovedArimoclomol is a hydroxylamine derivative [A264414] and a heat-shock protein-70 (HSP70) co-inducer. … [L51384] Arimoclomol was approved by the FDA on September 20, 2024, making it the first treatment for Niemann-Pick disease, type C (NPC).
Categories: MATE 2 Substrates, MATE 1 SubstratesSynonyms: 3-PYRIDINECARBOXIMIDOYL CHLORIDE, N-((2R)-2-HYDROXY-3-(1-PIPERIDINYL)PROPOXY), 1-OXIDE, N-[(2R)-2-Hydroxy-3-(1-piperidyl)propoxy]pyridine-3-carboximidoyl chloride, 1-oxideLatanoprost
go.drugbank.com/drugs/DB00654ApprovedInvestigationalAnother benefit latanoprost is that it can be administered once a day.[A184490] … Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998.
Mixtures: LATANOPROST 0.05 MG/ML AND TIMOLOL 5 MG/ML SANDOZ EYE DROPS, Xalacom 50 Mikrogramm/ml + 5 mg/ml AugentropfenCategories: Prostaglandins F, Synthetic, Compounds used in a research, industrial, or household settingMoclobemide
go.drugbank.com/drugs/DB01171ApprovedInvestigationalA reversible monoamine oxidase inhibitor (MAOI) selective for isoform A (RIMA) used to treat major depressive disorder.
Categories: Cytochrome P-450 Substrates, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: 4-Chlor-N-(2-morpholinoethyl)benzamid, p-Chloro-N-(2-morpholinoethyl)benzamideThenalidine
go.drugbank.com/drugs/DB04826ApprovedWithdrawnWithdrawn from the Canadian, US, and UK markets in 1963 due to concerns involving neutropenia.
Synonyms: 1-Methyl-4-N-2-thenylanilinopiperidine, 1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidineCategories: Heterocyclic Compounds, 1-RingSofpironium
go.drugbank.com/drugs/DB19325ApprovedSofpironium is a "soft" anticholinergic analog of [glycopyrronium] that has been modified with a readily hydrolyzable ester moiety. … [L51109] Soft drugs are designed to reduce systemic toxicity while enhancing local efficacy by employing retrometabolic drug design, in which a molecule contains a metabolically sensitive moiety that promotes
Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSynonyms: Pyrrolidinium, 3-(((2r)-2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy)-1-(2-ethoxy-2-oxoethyl)-1-methyl-, (3r)-Hexaminolevulinate
go.drugbank.com/drugs/DB06261ApprovedInvestigationalC (PDD) System for cystoscopic detection of non-muscle invasive papillary cancer of the bladder for patients suspected or known to have lesion(s) on the basis of a prior cystoscopy. … Hexaminolevulinate is manufactured under the brand Cysview® by Photocure ASA. In Europe, Hexaminolevulinate is marketed under the brand Hexvix®.
Synonyms: 4-Hexyloxycarbonyl-2-oxobutylammoniumchloride, Hexyl 5-amino-4-oxopentanoate hydrochlorideProducts: Hexvix 85 mg Pulver und Lösungsmittel zur Herstellung einer Lösung zur intravesikalen AnwendungIptacopan
go.drugbank.com/drugs/DB16200ApprovedInvestigationalB. … Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor
Categories: Heterocyclic Compounds, 2-Ring, Complement Factor B InhibitorSynonyms: 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl) benzoic acid, BENZOIC ACID, 4-((2S,4S)-4-ETHOXY-1-((5-METHOXY-7-METHYL-1H-INDOL-4-YL)METHYL)-2-PIPERIDINYL)-Lesinurad
go.drugbank.com/drugs/DB11560ApprovedWithdrawnserum uric acid levels with a xanthine oxidase inhibitor alone. … Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: {[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acidEluxadoline
go.drugbank.com/drugs/DB09272ApprovedInvestigationalEluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). … of both pain and diarrhea characteristic of IBS-D.
Categories: Heterocyclic Compounds, 1-Ring, mu-Opioid Receptor AgonistSynonyms: 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid