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Salsalate

Salsalate is readily soluble in the small intestine where it is partially hydrolyzed to two molecules of salicylic acid. … Salsalate is a nonsteroidal anti-inflammatory agent for oral administration.

M0002

M0002 is an orally-active selective vasopressin antagonist that inhibits water re-absorption from the kidneys. … It is a vasopressin 2 antagonist and represents a new class of compounds – aquaretics – that produce profound diuresis without loss of electrolytes.

Diacerein

It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea [L780]. … Diacerein is a prodrug which is metabolized to rhein.

ENMD-1198

Linsitinib

An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. IGF-1R inhibitor OSI-906 selectively inhibits IGF-1R, which may result in the inhibition of tum...

Alitretinoin

It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). … Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic.

Tezosentan

Tezosentan is an intravenous endothelin receptor A/B antagonist.

Calcitonin gene-related peptide

In particular, it is a potent endogenous vasodilator. … It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue.

Bethanidine

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

Perifosine

Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.