Bethanidine

DB00217ApprovedSmall molecule

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

Mechanism: Bethanidine, a guanidine derivative, is a peripherally acting antiadrenergic agent which primarily acts as an alpha2a adrenergic agonist. Bethanidine effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.
Curator reviewed
Primary indication: For the treatment of hypertension.Curator reviewed
Formula / weight: C₁₀H₁₅N₃ · 177.2462 g/mol (avg)
Also known as: Betanidine

Resolves to

Compound

UNIIW8S3YM7AUUCAS55-73-2ChEMBLCHEMBL1201260ChEBI37937PubChem2368KEGGD01603

Clinical / RWD

RxNorm1523ATCC02CC01PharmGKBPA164743235

Structure

InChIKeyNIVZHWNOUVJHKV-UHFFFAOYSA-NSMILESCN\C(NCC1=CC=CC=C1)=N/C

Targets

P23975SLC6A2P48048KCNJ1P08588ADRB1

What you can answer from here — as of September 13, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

764Drug interactionsStructured to mechanism, not free text

1ATC codeIncluding every combination product, plus 16 drug categories

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Bethanidine, and which of those have an active Phase 3 trial?

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