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4-Phenylfentanyl

4-Phenylfentanyl is a sythetic opioid derived from fentanyl. 4-Phenylfentanyl is around 8x the potency of fentanyl in analgesic tests on animals, but more complex 4-heteroaryl derivatives such as substituted … thiophenes and thiazoles are more potent still, as they are closer bioisosteres to the 4-carbomethoxy group of carfentanil.

Col-118

COL-118, a topical compound based on the SansRosa technology, for the treatment of redness associated with rosacea and other skin disorders. … It is a believed to reduce erythema by constricting enlarged blood vessels in facial tissue.

VPM1002

Because Hly is only active at an acidic pH, similar to listeriolysin O, the deletion of urease C was also beneficial for Hly to have optimal bioactivity in the phagosome. … As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials.

AX200

AX200, which has been developed for the treatment of stroke, is the most advanced drug candidate and is halfway through the process of gaining clinical approval. … Thus, if this drug administered in the acute phase of stroke, the brain’s own protective action is supported.

Resatorvid

Resatorvid is an investigational compound designed for the treatment of severe sepsis.

Sulfameter

Long acting sulfonamide used in leprosy, urinary, and respiratory tract infections.

Rotenone

Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also toxic to fish.

KD3010

KD3010 is a small molecule peroxisome proliferator-activator receptor delta (PPAR Delta) agonist for the treatment of metabolic disorders, including obesity.

Loprazolam

It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent nocturnal awakenings. … It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. It is not an FDA-approved drug.

p-Phenylenediamine