Search
Letrozole
go.drugbank.com/drugs/DB01006ApprovedInvestigational[A190546] Letrozole was granted FDA approval on 25 July 1997.[L11623] … [A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine.
Products: PMS-letrozole, LET®2.5MGBurosumab
go.drugbank.com/drugs/DB14012ApprovedInvestigationalIt causes impaired bone growth and development in children and adolescents and issues with bone mineralization throughout a patient’s life [L2346]. … Some adults with this condition suffer from persistent, unrelenting discomfort and complications, such as joint pain, impaired mobility, tooth abscesses and hearing loss [L2346].
Products: CRYSVITA ® SOLUCION PARA INYECCIÓN 10MG/MLSirolimus
go.drugbank.com/drugs/DB00877ApprovedInvestigational[A242412] It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after its potent antitumor and immunosuppressive activities were later discovered, it was … it was shown to regulate longevity and maintain normal glucose homeostasis.
Products: RAPAMUNE TABLET 1MG, RAPAMUNE TABLETS (1MG)Anagrelide
go.drugbank.com/drugs/DB00261ApprovedInvestigational[L14153] It is an oral imidazoquinazoline that was first approved for use in the US in 1997.[A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g.
Products: ANAGRELID ABZ 1MG, ANAGRELID RIBOSEPH 1MGPentoxyverine
go.drugbank.com/drugs/DB11186ApprovedWithdrawnIt is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists [A32160]. … Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate.
Products: PENTOXYVERIN AL 19MG/MLAcetylcholine
go.drugbank.com/drugs/DB03128ApprovedInvestigationalIt is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications. … Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in
Products: Miogan Pws 20mg/vial, Miochol ENorfloxacin
go.drugbank.com/drugs/DB01059ApprovedInvestigationalA synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Products: PMS-norfloxacin, NORFLOXACINA EGFluorescein
go.drugbank.com/drugs/DB00693ApprovedInvestigationalIt has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275) … A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal
Products: Fluorets - Stp Oph 1mg, FLUORESCEIN SERB 100MG/ML SOLUTION FOR INJECTIONSofosbuvir
go.drugbank.com/drugs/DB08934ApprovedInvestigationalNotably, sofosbuvir has come under intense scrutiny since its release to market in 2013. With the price per pill set at $1000, a 12-week treatment can cost upwards of $84,000 per patient [A19636]. … As a prodrug nucleotide analog, Sofosbuvir is metabolized into its active form as the antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-triphosphate (also known as GS-461203), which acts as a defective
Mixtures: VOSEVI FILM-COATED TABLETS 400MG/100MG/100MG, EPCLUSA TABLET 400MG/100MGProducts: SOVALDI TABLET 400MG, VIRSO Sofosbuvir Tablets 400mgTalazoparib
go.drugbank.com/drugs/DB11760ApprovedInvestigational[L47236] Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 [A260346] and by the EMA in June 2019.[L47296] It was approved by Health Canada in September 2020. … Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair.
Products: TALZENNA CAPSULE 1MG, Talzenna 1mg Hard Capsules