Norfloxacin is a broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Norfloxacin inhibits bacterial DNA gyrase.
- Mechanism
- Curator reviewed
The bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic agent that is shown to be effective against various Gram-positive and Gram-negative bacterial species. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomonal activity
- Primary indication
- For the treatment of urinary tract infectionCurator reviewed · 8 structured indications
- Formula / weight
- C16H18FN3O3 · 319.3308 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1986
- Also known as
- NFLX
- Code names
- MK-366
Resolves to
OGJPXUAPXNRGGI-UHFFFAOYSA-NSMILESCCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCNCC1What you can answer from here — as of September 23, 2026
Which drugs share a target with Norfloxacin, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account