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Displaying results 571 - 580 of 10000 in total
  1. Drug

    Cefixime

    go.drugbank.com/drugs/DB00671
    ApprovedInvestigational

    [A263026] However, cefixime is not recommended as a first-line of treatment for uncomplicated urogenital, anorectal, or pharyngeal gonorrhea because cefixime does not provide the same bactericidal effect … [A262995] Third-generation cephalosporins are often a first-line therapy against certain bacterial infections.

    Mixtures: MOLCEF PLUS 100/62.5/5 ML ORAL SUSPANSIYON HAZIRLAMAK ICIN KURU TOZ, 100 ML, MOLCEF PLUS 200 MG+62.5/5 ML ORAL SÜSPANSİYON HAZIRLAMAK İÇİN KURU TOZ, 100 MLCategories: Heterocyclic Compounds, 2-Ring
  2. Drug

    Infliximab

    go.drugbank.com/drugs/DB00065
    ApprovedInvestigational

    Infliximab is produced by a recombinant cell line cultured by continuous perfusion. … alternative first-line therapies for that disorder [FDA Label].

    Synonyms: IMMUNOGLOBULIN G (HUMAN-MOUSE MONOCLONAL CA2 HEAVY CHAIN ANTI-HUMAN TUMOR NECROSIS FACTOR), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL CA2 LIGHT CHAIN, DIMERProducts: REMICADE 100MG PUL Z H INF, Remsima 120mg solution for injection in pre-filled pen
  3. Drug

    Arsenic trioxide

    go.drugbank.com/drugs/DB01169
    ApprovedInvestigational

    Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. … In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsProducts: TRIOSSIDO DI ARSENICO MYLAN, TRIOSSIDO DI ARSENICO MEDAC
  4. Drug

    Iohexol

    go.drugbank.com/drugs/DB01362
    ApprovedInvestigational

    Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. … Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures.

    Mixtures: Dexlido M-C, Mlk F4-CCategories: Compounds used in a research, industrial, or household setting, Diagnostic Uses of Chemicals
  5. Target

    Diacylglycerol O-acyltransferase 2

    go.drugbank.com/bio_entities/BE0008719
    EnzymeTargetHumans

    Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). … Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.

    Polypeptides: Diacylglycerol O-acyltransferase 2Synonyms: Retinol O-fatty-acyltransferase, Acyl-CoA retinol O-fatty-acyltransferase
  6. Target

    Diacylglycerol O-acyltransferase 1

    go.drugbank.com/bio_entities/BE0012021
    TargetHumans

    Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (PubMed:18768481). … In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:16214399).

    Polypeptides: Diacylglycerol O-acyltransferase 1Synonyms: Retinol O-fatty-acyltransferase, Acyl-CoA retinol O-fatty-acyltransferase
  7. Drug

    Etanercept

    go.drugbank.com/drugs/DB00005
    ApprovedInvestigational

    Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids. … It is used to treat or manage a variety of inflammatory conditions including rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic poly-articular arthritis (JIA).

    Products: BENEPALI 50MG ILO I E FER, BENEPALI 50MG ILO I PEN
  8. Drug

    Remifentanil

    go.drugbank.com/drugs/DB00899
    ApprovedInvestigational

    Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. … Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Heterocyclic Compounds, 1-RingProducts: REMIFENTANIL MYLAN GENERICS, REMIFENTANILO 2MG POLVO PARA RECONSTITUIR A SOLUCION INYECTABLE O INFUSION INTRAVENOSA
  9. Drug

    Coagulation Factor IX Human

    go.drugbank.com/drugs/DB13152
    ApprovedInvestigational

    Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B.

    Synonyms: Antihemophilic factor B, Factor IX (Human)Mixtures: Beriplex P/n 500, Beriplex P/n 1000
  10. Target

    Membrane protein involved in aromatic hydrocarbon degradation

    go.drugbank.com/bio_entities/BE0003979
    TargetPseudomonas putida (strain F1 / ATCC 700007)

    Polypeptides: Membrane protein involved in aromatic hydrocarbon degradation