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Displaying results 5821 - 5830 of 8974 in total
  1. Target

    Cytochrome P450 1A1

    go.drugbank.com/bio_entities/BE0009369
    EnzymeRat

    Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). … Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997).

    Synonyms: Cytochrome P450 form 6
  2. Drug

    IPH 2101

    go.drugbank.com/drugs/DB06049
    Investigational

    IPH-2101 (NN-1975), a fully human monoclonal antibody developed for patients with acute myeloid leukemia.

  3. Drug

    MOR-22

    go.drugbank.com/drugs/DB17790
    Experimental

    MOR-22, a Natural human lymphoblastoid interferon-alpha, is currently being investigated to treat papillomavirus warts in the oral cavity of HIV-positive patients.

  4. Drug

    Debamestrocel

    go.drugbank.com/drugs/DB17934
    Investigational

    Debamestrocel is under clinical development by BrainStorm Cell Therapeutics and is being investigated for the treatment of Amyotrophic Lateral Sclerosis (ALS).[L47266]

  5. Drug

    Virginiamycin M1

    go.drugbank.com/drugs/DB01669
    Experimental

    It is produced by Streptomyces graminofaciens and other bacteria.

  6. Drug

    Exisulind

    go.drugbank.com/drugs/DB06246
    Investigational

    Categories: Compounds used in a research, industrial, or household setting
  7. Drug

    XEN-2174

    go.drugbank.com/drugs/DB05012
    Experimental

    In episodes of pain, inhibition of NET by XEN-2174 elevates the levels of NE leading to the activation of inhibitory pathways preventing pain signals from reaching the brain.

  8. Target

    Cytochrome P450 2C8

    go.drugbank.com/bio_entities/BE0002887
    TargetEnzymeHumans

    It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316) … Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772).

    Synonyms: Cytochrome P450 form 1
  9. Drug

    Benziodarone

    go.drugbank.com/drugs/DB13277
    ApprovedWithdrawn

    It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T487, A175636].

  10. Drug

    Cilansetron

    go.drugbank.com/drugs/DB04885
    Experimental

    Cilansetron is a 5HT-3 antagonist made by Solvay Pharmaceuticals that is currently under trial phase in the EU and US.

    Categories: Drugs for Functional Gastrointestinal Disorders