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Displaying results 5841 - 5850 of 10000 in total
  1. Drug

    1D09C3

    go.drugbank.com/drugs/DB05121
    Experimental

    1D09C3, a monoclonal antibody against lymphoid cancers, is an anti-MHC (major histocompatibility complex) class II monoclonal antibody. … class II-positive tumor cells, which include those in B-cell and T-cell lymphomas. 1D09C3 has been shown to induce programmed cell death and does not require a functioning immune system for its cell-killing

  2. Drug

    XL844

    go.drugbank.com/drugs/DB05149
    Investigational

    XL844 is a potent inhibitor of the checkpoint kinases CHK1 and CHK2, which induce cell cycle arrest in response to a variety of DNA damaging agents. … XL844 is investigated for the use and treatment solid tumors. XL844 is a solid.

  3. Drug

    Anti-SARS-CoV-2 IgY

    go.drugbank.com/drugs/DB16356
    Investigational

    [L27381] To create these antibodies, chickens are injected in the chest with the spike protein, which is the surface protein of SARS-CoV-2; this results in an immune response mounted by the chickens towards … From there, the chicken antibodies are harvested from the egg yolks of the eggs laid by these chickens and formulated into the nasal drops that can be administered.

  4. Drug

    Secretin porcine

    go.drugbank.com/drugs/DB09527
    ApprovedWithdrawn

    Secretin porcine stimulates pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma.

  5. Pathway

    Autophagy

    smpdb.ca/view/SMP0578913
    Signaling

    Furthermore, in pathological contexts such as tumor cells exposed to photodynamic therapy, upregulation of cytoprotective autophagy can foster treatment resistance by removing damaged components and mitigating … Dysregulation of autophagy has been implicated in a spectrum of human diseases, including metabolic disorders (insulin resistance, diabetes, obesity), cancer (where it can act as both a tumor suppressor

    Drugs: Adenosine phosphate · Calcium
    Enzymes: Activating molecule in BECN1-regulated autophagy protein 1
  6. Drug

    Altropane

    go.drugbank.com/drugs/DB04947
    Investigational

    Boston Life Sciences (BLS) is developing Altropane as a potential radio-imaging agent to be used with single photon emission tomography (SPECT), for the early diagnosis of Parkinson's disease (PD) and

  7. Drug

    Methoxyamine

    go.drugbank.com/drugs/DB06328
    Investigational

  8. Drug

    Efalizumab

    go.drugbank.com/drugs/DB00095
    ApprovedWithdrawn

    Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. … The FDA approved efalizumab in 2003. It was later withdrawn in 2009 due to a potential risk of progressive multifocal leukoencephalopathy (PML).[L43797]

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents
  9. Drug

    Casein

    go.drugbank.com/drugs/DB10516
    Approved

    Casein allergenic extract is used in allergenic testing.

    Categories: Compounds used in a research, industrial, or household setting, Fluids and Secretions
  10. Drug

    Platelet Lysate

    go.drugbank.com/drugs/DB15869
    Investigational

    Platelet lysate is an acellular compound composed of platelet proteins while also being void of cellular debris, thus making the lysate rich with growth factors. … [A220188] It is extracted through lysis of the plasma membrane of platelets. Because white cell antigens are low in prepared lysate, there is a minimized likelihood of immune responses.