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Ocrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigationalPrimary progressive multiple sclerosis (PPMS) accounts for 10-15% of the overall population of patients with MS, and leads to the gradual worsening of neurologic disability from symptom onset, often without … [A18875,A251745] MS is a chronic, inflammatory, autoimmune disease of the central nervous system that leads to neurological disabilities and a significantly reduced quality of life.
Products: OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 2 ADET, OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETPoloxamer 188
go.drugbank.com/drugs/DB11333ApprovedDue to its sufactant properties, P188 may also be found in over-the-counter (OTC) products such as toothpaste, laxatives and mouthwash, and used in various cosmetic, industrial and pharmaceutical applications … The use of P188 as a potential treatment in different pathological conditions, such as chronic microvascular diseases and skeletal muscle deficiencies, is under investigation [A27217].
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 CYP3A InhibitorsProducts: Kang Du Qing, Mayer /Kang Du QingAnagrelide
go.drugbank.com/drugs/DB00261ApprovedInvestigational[L14153] It is an oral imidazoquinazoline that was first approved for use in the US in 1997.[A214274] It appears to carry a better response rate than other thrombocythemia treatments (e.g. … Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesProducts: ANAGRELID AL 0.5MG HKP, ANAGLYN 0,5 MG SERT KAPSÜL, 100 KAPSÜLVitamin E
go.drugbank.com/drugs/DB00163ApprovedInvestigationalNutraceuticalVet approvedVitamin E acts as an antioxidant, protecting cell membranes from oxidative damage[A176104]. … In 1922, vitamin E was demonstrated to be an essential nutrient[A32448].
Mixtures: EVİNA E+C 100 IU/500 MG YUMUŞAK KAPSÜL, 20 ADET, VITAMIN D3 1.25 MG 50000 IU Dietary SupplementCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesBusulfan
go.drugbank.com/drugs/DB01008ApprovedInvestigationalBusulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. … According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesProducts: MYLERAN 2 MG TABLET, 100 ADET, BUSULFAN SOLUCIÓN INYECTABLE 60 MG/10 MLNilotinib
go.drugbank.com/drugs/DB04868ApprovedInvestigationalNilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). … ), another tyrosine kinase inhibitor used as a first-line treatment for CML.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: TASIGNA® 150 MG CAPSULAS, TASIGNA 150 MG KAPSUL, 28 ADETCarboxymethylcellulose
go.drugbank.com/drugs/DB11059ApprovedInvestigationalIt is added in food products as a viscosity modifier or thickener and emulsifier. … The viscous and mucoadhesive properties as well as its anionic charge allow prolonged retention time in the ocular surface [A33029]. Sodium carboxymethylcellulose is the most commonly used salt.
Mixtures: OPTIVE FUSION UD, OPTIVE FUSION® UDCategories: Compounds used in a research, industrial, or household settingMelatonin
go.drugbank.com/drugs/DB01065ApprovedInvestigationalNutraceuticalVet approvedReduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers. … The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus
Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesProducts: Insovef 1 mg/mL Oral Çözelti, 150 ML, Melatonin Rapid Release Gelcaps 10 mgRifabutin
go.drugbank.com/drugs/DB00615ApprovedInvestigationalA broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersProducts: Mycobutin 150 mg - Kapseln, RIFBUTIN® 150 MG CAPSULASCysteamine
go.drugbank.com/drugs/DB00847ApprovedInvestigationalCystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. … [L15606] Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis.
Products: CYSTAGON ® 150 MG, CYSTAGON ® 50 MG CAPSULAS