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Didanosine Anti-viral Action Pathway
smpdb.ca/view/SMP0124953Drug actionWhen HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing its RNA and reverse transcriptase into the cytosol of the cell. … Less viral proteins are therefore produced, and there is a reduction in new viruses being formed.
Ledipasvir Action Pathway
smpdb.ca/view/SMP0125940Drug actionThe lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. … The nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the structural components of HCV virions.
Elbasvir Action Pathway
smpdb.ca/view/SMP0125944Drug actionThe lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. … The nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the structural components of HCV virions.
Glecaprevir Action Pathway
smpdb.ca/view/SMP0125953Drug actionThe lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. … NS5A, and NS5B.
Bamlanivimab Action Pathway
smpdb.ca/view/SMP0126053Drug actionX-ray crystallography and cryo-EM structural determination suggest that this molecule binds the receptor-binding domain (RBD) of the spike protein of CoV-19. … Bamlanivimab is available as an intravenous injection.
Sofosbuvir Action Pathway
smpdb.ca/view/SMP0126154Drug actionThe lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. … The nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the structural components of HCV virions.
Leukotriene C4 Synthesis Deficiency
smpdb.ca/view/SMP0000353DiseaseA defect in LTC4 results in decreased concentrations of cysteinyl leukotrienes LTC4, LTD4 and LTE4 in plasma, spinal fluid and urine. … Leukotriene C4 and its receptor-binding metabolites LTD4 and LTE4 are cysteinyl leukotrienes that are potent lipid mediators of tissue inflammation.
Etodolac Action Pathway
smpdb.ca/view/SMP0000084Drug actionThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … The increase in intracellular calcium activates kinases required for morphological change, transition to procoagulant surface, secretion of granular contents, activation of glycoproteins, and the activation
Rofecoxib Action Pathway
smpdb.ca/view/SMP0000087Drug actionThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … The increase in intracellular calcium activates kinases required for morphological change, transition to procoagulant surface, secretion of granular contents, activation of glycoproteins, and the activation
Valdecoxib Action Pathway
smpdb.ca/view/SMP0000116Drug actionThis in turn inhibits the calcium-dependent events, including PLA2 activation, involved in platelet activation and aggregation. … The increase in intracellular calcium activates kinases required for morphological change, transition to procoagulant surface, secretion of granular contents, activation of glycoproteins, and the activation