Etodolac is an NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties.
- Mechanism
- Curator reviewed
Similar to other NSAIDs, the anti-inflammatory effects of etodolac result from inhibition of the enzyme cycooxygenase (COX). This decreases the synthesis of peripheral prostaglandins involved in mediating inflammation. Etodolac binds to the upper portion of the COX enzyme active site and prevents its substrate, arachidonic acid, from entering the active site. Etodolac was previously thought to be a non-selective COX inhibitor, but it is now known to be 5 – 50 times more selective for COX-2 than COX-1. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
- Primary indication
- For acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, as well as for the management of pain.Curator reviewed · 18 structured indications
- Formula / weight
- C17H21NO3 · 287.3535 g/mol (avg)
- First approval
- Canada, 1994 · United States, 1993
- Also known as
- Etodolic acid
- Code names
- AY-24,236 · NIH-9918
- Brand names
Resolves to
NNYBQONXHNTVIJ-UHFFFAOYSA-NSMILESCCC1=C2NC3=C(CCOC3(CC)CC(O)=O)C2=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Etodolac, and which of those have an active Phase 3 trial?
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