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Displaying results 6091 - 6100 of 10000 in total
  1. Target

    Syndecan-1

    go.drugbank.com/bio_entities/BE0010357
    TargetHumans

    Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660...

    Polypeptides: Syndecan-1
  2. Target

    Thrombospondin-1

    go.drugbank.com/bio_entities/BE0010410
    TargetHumans

    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions (PubMed:15014436, PubMed:18285447, PubMed:2430973, PubMed:6489349). Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen ...

    Polypeptides: Thrombospondin-1
  3. Target

    Prominin-1

    go.drugbank.com/bio_entities/BE0010464
    TargetHumans

    May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epi...

    Polypeptides: Prominin-1Synonyms: Prominin-like protein 1
  4. Target

    Stabilin-1

    go.drugbank.com/bio_entities/BE0010944
    TargetHumans

    Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, ...

    Polypeptides: Stabilin-1Synonyms: FEEL-1, MS-1 antigen
  5. Target

    Interleukin-1

    go.drugbank.com/bio_entities/BE0010992
    TargetHumans

    Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). … After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex (PubMed:17507369, PubMed:2950091).

    Polypeptides: Interleukin-1 alpha, Interleukin-1 betaSynonyms: IL-1 alpha, IL-1 beta
  6. Target

    Calmodulin-1

    go.drugbank.com/bio_entities/BE0012563
    TargetHumans

    Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:23893133, PubMed:2696975...

    Polypeptides: Calmodulin-1
  7. Target

    Cholinephosphotransferase 1

    go.drugbank.com/bio_entities/BE0017642
    TargetHumans

    Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the format...

    Polypeptides: Cholinephosphotransferase 1Synonyms: Diacylglycerol cholinephosphotransferase 1
  8. Target

    Syncytin-1

    go.drugbank.com/bio_entities/BE0020919
    TargetHumans

    This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4...

    Polypeptides: Syncytin-1Synonyms: Endogenous retrovirus group W member 1
  9. Target

    Frizzled-1

    go.drugbank.com/bio_entities/BE0020982
    TargetHumans

    Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B ...

    Polypeptides: Frizzled-1Synonyms: Fz-1
  10. Drug

    Metyrapone

    go.drugbank.com/drugs/DB01011
    ApprovedInvestigational

    An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2A6 InhibitorsProducts: Metycor 250 mg Weichkapseln