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Displaying results 611 - 620 of 10000 in total
  1. Drug

    Fluoroestradiol F-18

    go.drugbank.com/drugs/DB15690
    ApprovedInvestigational

    [L14096] The ability to image ER-positive tumors _in vivo_ is advantageous in that, while helping to visualize tumor progression/regression, it may also be used to assess for heterogeneity in ER expression … across metastases (i.e. to identify sites that no longer express ER) without the need for multiple biopsies.

  2. Drug

    Pregabalin

    go.drugbank.com/drugs/DB00230
    ApprovedInvestigational

    Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. … [L1006,L7066] It may have dependence liability if misused but the risk appears to be highest in patients with current or past substance use disorders.[A31161]

    Products: PREGABALIN EG, EPIBALIN ER 330 MG
  3. Drug

    Azilsartan medoxomil

    go.drugbank.com/drugs/DB08822
    ApprovedInvestigational

    As hypertension is a major risk factor for cardiovascular disease,[A7354] early management of hypertension has several implications on patients' survival rate and quality of life in the future. … enzyme (ACE) inhibitors that are also used as first-line treatment for hypertension.

    Categories: Agents Acting on the Renin-Angiotensin System
  4. Drug

    Topiramate

    go.drugbank.com/drugs/DB00273
    ApprovedInvestigational

    [A175249] It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults. … [A188309,L10544,L43478] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults.

    Products: TOPIRAMATO EG, Topamax 15 mg Granulat in Kapseln
  5. Drug

    Belinostat

    go.drugbank.com/drugs/DB05015
    ApprovedInvestigational

    The safety and efficacy of belinostat is currently being evaluated for use in combination with traditional front-line therapies for the treatment of PTCL. … It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget.

    Synonyms: (2E)-N-HYDROXY-3-(3-(PHENYLSULFAMOYL)PHENYL)PROP-2-ENAMIDE, N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide
  6. Drug

    Padimate O

    go.drugbank.com/drugs/DB11570
    Approved

    Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA [L2153]. … It penetrates human skin, and is shown to induce non-ligatable strand breaks on DNA _in vitro_ and mutagenic effects on yeast i_n vivo_ [A32458].

    Mixtures: Lotion Solaire Haute Protection Fps 15, Banana Boat Sunscreen Oil Spray Huile Écran Solaire En Vaporisateur SPF Fps 4Categories: Compounds used in a research, industrial, or household setting
  7. Drug

    Lindane

    go.drugbank.com/drugs/DB00431
    ApprovedWithdrawn

    In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical … treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment.

    Categories: Compounds used in a research, industrial, or household setting
  8. Drug

    Ambroxol

    go.drugbank.com/drugs/DB06742
    ApprovedInvestigational

    Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents. … role in the body’s natural defence mechanisms.

    Mixtures: LARITOL EX, TUKOL EXSynonyms: Cyclohexanol, 4-((2-amino-3,5-dibromobenzyl)amino)- (E)-, N-(2-Amino-3,4-dibromociclohexil)-trans-4-aminociclohexanol
  9. Drug

    Propiverine

    go.drugbank.com/drugs/DB12278
    Approved

    OAB has a negative impact on quality of life and may lead to leakage and inconvenient urinary accidents [L2327], [L2328]. … The impact of OAB on quality of life is sometimes devastating, especially to elderly patients with other medical conditions [L2328].

  10. Drug

    Tilmicosin

    go.drugbank.com/drugs/DB11471
    InvestigationalVet approved

    It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with _Mannheimia haemolytica_.

    Products: EM-MICOFEED 10% Granules