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Displaying results 621 - 630 of 10000 in total
  1. Drug

    Nortriptyline

    go.drugbank.com/drugs/DB00540
    ApprovedInvestigational

    Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA). … [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]

    Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT1 Receptor AntagonistsSynonyms: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine
  2. Drug

    Phytochlorin

    go.drugbank.com/drugs/DB19265
    Investigational

    Phytochlorin is under investigation in clinical trial NCT06311890 (Study to Evaluate the Efficacy, Safety and Tolerability of Photodynamic Therapy(pdt) With Chlorin-e6 in Treating Moderate to Severe Acne

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsSynonyms: 2-porphinepropionic acid, 18-carboxy-20-(carboxymethyl)-13-ethyl-2.beta.,3-dihydro-3.beta.,7,12,17-tetramethyl-8-vinyl-, 21h,23h-porphine-2-propanoic acid, 18-carboxy-20-(carboxymethyl)-8-ethenyl-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-, (2s-trans)-
  3. Drug

    Levothyroxine

    go.drugbank.com/drugs/DB00451
    ApprovedInvestigational

    deiodination (by type I or type II 5′-deiodinases)[A179941] into its active metabolite T<sub>3</sub>. … potency of ~1:4 (T4:T3).

    Mixtures: BITIRON 50 MCG/12.5 MCG TABLET, 100 ADET, SYNTHROID® 112 MCG TABLETASCategories: P-glycoprotein inducers, Cytochrome P-450 CYP2C8 Inhibitors
  4. Drug

    Flurpiridaz F-18

    go.drugbank.com/drugs/DB18773
    Approved

    [A264519] Flurpiridaz F-18 is an analog of pyridaben, a mitochondrial complex 1 (MC-1) inhibitor.[L51659] … Flurpiridaz F-18 is a radioactive diagnostic drug indicated for positron emission tomography (PET) myocardial perfusion imaging (MPI), which is an imaging process used in patients with known or suspected

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 3(2h)-pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-((4-((2-(fluoro-(sup 18)f)ethoxy)methyl)phenyl)methoxy)-, 4-chloro-2-(1,1-dimethylethyl)-5-((4-((2-((sup 18)f)fluoroethoxy)methyl)phenyl) methoxy)pyridazin-3(2h)-one
  5. Drug

    Archexin

    go.drugbank.com/drugs/DB05971
    Investigational

    Synonyms: 20-mer complementary to Akt mRNA, 5'-DG-DC-T-DG-DC-DA-T-DG-DA-T-DC-T-DC-DC-T-T-DG-DG-DC-DG-3'
  6. Drug

    Riociguat

    go.drugbank.com/drugs/DB08931
    ApprovedInvestigational

    Riociguat is marketed under the brand Adempas® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment. … Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesSynonyms: Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate
  7. Drug

    Dordaviprone

    go.drugbank.com/drugs/DB14844
    ApprovedInvestigational

    Factor 4 (ATF4), and induction of endoplasmic reticulum (ER) stress response. … [L53838] It is used to treat patients with diffuse midline glioma harboring an H3 K27M mutation.

    Categories: MATE 2 Inhibitors, MATE 1 InhibitorsSynonyms: 2,4,6,7,8,9-Hexahydro-4-((2-methylphenyl)methyl)-7-phenylmethyl)imidazo)(1,2-a)pyrido(3,4-e)pyrimidin-5(1H)-one, 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo(1,2-A)pyrido(3,4-E)pyrimidin-5(4H)-one
  8. Drug

    Ginsenoside Rg3

    go.drugbank.com/drugs/DB19257
    Investigational

    Ginsenoside Rg3 is under investigation in clinical trial NCT01757366 (Safety and Efficacy of Ginsenoside Rg3 in Combination With First-line Chemotherapy in Advanced Gastric Cancer).

    Synonyms: -d-glucopyranoside, (3.beta.,12.beta.)-12,20-dihydroxydammar-24-en-3-yl 2-o-.beta.-d-glucopyranosyl-, 20(s)-ginsenoside-rg3
  9. Drug

    Azaribine

    go.drugbank.com/drugs/DB19364
    ApprovedWithdrawn

    Synonyms: 6-azauridine 2',3',5'-triacetate, 2-.beta.-d-ribofuranosyl-as-triazine-3,5(2h,4h)-dione 2',3',5'-triacetateCategories: Heterocyclic Compounds, 1-Ring
  10. Drug

    3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide

    go.drugbank.com/drugs/DB08092
    Experimental

    3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide is a solid. This compound belongs to the phenylmorpholines. … These are aromatic compounds containing a morpholine ring and a benzene ring linked to each other through a CC or a CN bond. This drug targets mitogen-activated protein kinase 14.

    Synonyms: 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide