Archexin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Archexin
Accession Number
DB05971
Description
Not Available
Type
Small Molecule
Groups
Investigational
Synonyms
Not Available
External IDs
  • RX-0201
  • RX-201

Pharmacology

Indication

Investigated for use/treatment in solid tumors.

Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action

RX-0201 is a first-in-class signal inhibitor that directly represses the production of Akt, a protein kinase that plays a key role in cancer progression. A less toxic therapeutic approach to cancer treatment, RX-0201 blocks the growth of tumor cells and promotes cell death (apoptosis).

TargetActionsOrganism
URAC-alpha serine/threonine-protein kinaseNot AvailableHumans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

International/Other Brands
Archexin

Categories

Drug Categories
Not Available
Classification
Not classified

Chemical Identifiers

UNII
4TEW51C830
CAS number
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentPancreatic Cancer Metastatic1
1, 2TerminatedTreatmentMetastatic Renal Cell Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Protein serine/threonine/tyrosine kinase activity
Specific Function
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, ...
Gene Name
AKT1
Uniprot ID
P31749
Uniprot Name
RAC-alpha serine/threonine-protein kinase
Molecular Weight
55686.035 Da

Drug created on November 18, 2007 11:29 / Updated on June 12, 2020 10:52