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PRGN-3006
go.drugbank.com/drugs/DB17229InvestigationalPRGN-3006 are autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane-bound interleukin-15, and a truncated form of human HER1T (kill switch) on the cell surface
Synonyms: PRGN-3006 UltraCAR-T, Autologous CD3+ T cells genetically modified using a non-viral system to express a CD33 CAR, membrane bound Interleukin-15, and a truncated form of human HER1t (kill switch) on the cell surfaceEfimosfermin alfa
go.drugbank.com/drugs/DB28564InvestigationalEfimosfermin Alfa is under investigation in clinical trial NCT07221188 (A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected … Efimosfermin Alfa is a biologic drug.
Dalzanemdor
go.drugbank.com/drugs/DB21549InvestigationalDalzanemdor is under investigation in clinical trial NCT05655520 (A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease). … Dalzanemdor is a small molecule drug.
QR-333
go.drugbank.com/drugs/DB05533Investigationalthat can lead to numbness, skin ulcers, constant pain or extreme sensitivity to a stimulus. … QR-333 is a concentrated and standardized nutrient based active compounds dosed in a topical cream designed to reduce oxidative stress and treat symptoms of Diabetic Peripheral Neuropathy, a nerve disorder
OSI-930
go.drugbank.com/drugs/DB05913InvestigationalOSI-930 is an orally active inhibitor of two clinically validated targets: c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2). … OSI-930 is designed to target both cancer cell proliferation and blood vessel growth (angiogenesis) in selected tumors.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingNavitoclax
go.drugbank.com/drugs/DB12340InvestigationalNavitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer. … It blocks some of the enzymes that keep cancer cells from dying.
Synonyms: (R)-4-(3-Morpholin-4-Yl-1-Phenylsulfanylmethyl-Propylamino)-N-(4-{4-[2-(4-Chlorophenyl)-5,5-Dimethylcyclohex-1-Enylmethyl]-Piperazin-1-Yl}-Benzoyl)-3-TrifluoromethanesulfonylbenzenesulfonamideMirfentanil
go.drugbank.com/drugs/DB09175ExperimentalMirfentanil is a derivative of fentanyl that presents high selectivity for the mu opioid receptor. … At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.
Categories: Heterocyclic Compounds, 1-RingLoprazolam
go.drugbank.com/drugs/DB13643ExperimentalLoprazolam is recommended as a short-term therapy only, due to adverse events associated with the drug including dependence and withdrawal symptoms. … It is a positive modulator of GABA-A receptor that enhances the inhibitory neurotransmission. It is not an FDA-approved drug.
Categories: Heterocyclic Compounds, 2-RingAdakitug
go.drugbank.com/drugs/DB05484InvestigationalTrials will initially focus on studies to treat glioblastoma, a cancer of the central nervous system. … MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation.
Synonyms: HuMax IL-8, HuMax-IL-8Egg phospholipids
go.drugbank.com/drugs/DB14233ApprovedWithdrawnEgg phospholipids are primarily a mixture of naturally occurring phospholipids which are isolated from the egg yolk. … Egg phospholipids are available as an intravenous fat emulsion indicated as a source of calories for patients requiring parenteral nutrition.
Mixtures: LIPOFUNDIN N EMULSION FOR INFUSION 20 %