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Brigatinib
go.drugbank.com/drugs/DB12267ApprovedInvestigational[A31311] It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a pivotal player in the transformation of susceptible lung parenchyma. … [A31313] Brigatinib was developed by Ariad Pharmaceuticals, a subsidiary of Takeda Pharmaceutical Company Limited, and FDA-approved on April 28, 2017.[L1026]
Mixtures: ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 23 ADET 180 MG, ALUNBRİG 90 MG VE 180 MG FİLM KAPLI TABLET TEDAVİYE BAŞLANGIÇ PAKETİ, 7 ADET 90 MG VE 23 ADET 180 MGCategories: MATE 2 Inhibitors, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawn3 patients. … Daclatasvir is a direct-acting antiviral agent against Hepatitis C Virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: DAKLINZA 30 MG FILM KAPLI TABLET ,FILM KAPLI TABLET, 28 ADET, I-HEP CLASTAVIR 30Cilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalIt is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. … It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States.
Mixtures: ACEPRIX PLUS 5 MG/12.5 MG FILM TABLET, 30 ADET, INHIBACE PLUS 5 MG TABLET, 28 ADETCategories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-RingTopiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigational[L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen. … Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996.
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP3A InducersSynonyms: 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate, 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamateValdecoxib
go.drugbank.com/drugs/DB00580ApprovedWithdrawnValdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Categories: COX-2 Inhibitors, Selective Cyclooxygenase 2 Inhibitors (NSAIDs)Products: BEXTRA®20 MG TABLETAS RECUBIERTAS, BEXTRA (R) 40 MG TABLETAS RECUBIERTASAzilsartan medoxomil
go.drugbank.com/drugs/DB08822ApprovedInvestigationalIt is also available in a combination product with [chlorthalidone]. … It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in February 2011.
Mixtures: EDARBI CLD®, EDARBYCLOR (TABLETS) 40 MG/12.5 MGCategories: Angiotensin 2 Receptor Blocker, Heterocyclic Compounds, 2-RingNaltrexone
go.drugbank.com/drugs/DB00704ApprovedInvestigationalVet approvedDerivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. … It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction.
Categories: Heterocyclic Compounds with 4 or More RingsSynonyms: N-Cyclopropylmethyl-14-hydroxydihydromorphinone, N-CyclopropylmethylnoroxymorphoneVenlafaxine
go.drugbank.com/drugs/DB00285ApprovedInvestigationalVenlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). … It was also considered a second-line treatment for obsessive-compulsive disorder (OCD).
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: VENOXOR®75 MG, EFEXOR® XR 37.5 MG CAPSULASCalcium
go.drugbank.com/drugs/DB01373ApprovedInvestigationalNutraceuticalLow calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. … Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium.
Mixtures: BONMEGA 70 MG/2800 IU+1000 MG TEDAVI PAKETI, 4+24 ADET, OSSOFORTIN A 70 MG+1200 MG/800 IU TEDAVİ PAKETİ, 4+24 ADETCategories: ascorbic acid (vit C) and calciumMacitentan
go.drugbank.com/drugs/DB08932ApprovedInvestigationalMacitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013. … A combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October 2021 for the treatment of PAH.[L39105] It was subsequently approved by the FDA in March 2024.
Mixtures: OPSYNVI® (MACITENTAN/TADALAFILO) 10MG/40 MG TABLETAS RECUBIERTASCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring