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Canagliflozin
go.drugbank.com/drugs/DB08907ApprovedInvestigational2 diabetes mellitus [L5897], [FDA label]. … Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise
Mixtures: VOKANAMET ® TM_TABLETAS RECUBIERTAS 150/1000 MG, VOKANAMET 50 MG/500 MGCategories: Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors, Cytochrome P-450 SubstratesEtravirine
go.drugbank.com/drugs/DB06414ApprovedInvestigationalOn March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 years of age, weighing at least 16 kg. … Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: INTELENCE®TABLETAS 200MG, INTELENCE TABLET 200 MGPrasugrel
go.drugbank.com/drugs/DB06209ApprovedInvestigationalSimilar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. … Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProducts: PRASUGREL BETA 5 MG FTA, Prasulan 5 mg-FilmtablettenBicalutamide
go.drugbank.com/drugs/DB01128ApprovedInvestigationalIt is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: CASODEX® 150 MG, BICAN ® 50 MG TABLETASTrospium
go.drugbank.com/drugs/DB00209ApprovedInvestigationalTrospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: TROSBIO® 30 MG, TROSBIO® 15 MGRoxadustat
go.drugbank.com/drugs/DB04847ApprovedInvestigationalRoxadustat is a first-in-class hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia associated with chronic kidney disease. … It works by reducing the breakdown of the hypoxia-inducible factor (HIF), which is a transcription factor that stimulates red blood cell production in response to low oxygen levels.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesProducts: Ernevod 20 mg Film Kaplı Tablet (12 adet), EVRENZO 20 MG FİLM KAPLI TABLET, 12 ADETCarfilzomib
go.drugbank.com/drugs/DB08889ApprovedInvestigationalChemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: ANPROTSOM ® 60 MG, Kyprolis 30 mg IV İnfüzyonluk Çözelti Hazırlamak İçin Toz, 1 ADETProlyl 4-hydroxylase subunit alpha-2
go.drugbank.com/bio_entities/BE0002253TargetHumansCatalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins
Polypeptides: Prolyl 4-hydroxylase subunit alpha-2Synonyms: 4-PH alpha-2, Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2Lisdexamfetamine
go.drugbank.com/drugs/DB01255ApprovedInvestigationalLisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine,[A40246] covalently attached to the naturally occurring amino acid L-lysine.
Products: SAMEXID® 30 MG, VYVANSE® 40 MG CAPSULASEtamsylate
go.drugbank.com/drugs/DB13483InvestigationalProducts: QUERCETOL® 250 MG/2 ML SOLUCION INYECTABLE., DICYNONE INJECTION 250 mg/2 ml