Etamsylate
Star1
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Etamsylate is a hemostatic agent that acts by restoring capillary resistance and improving platelet adhesion.
- Generic Name
- Etamsylate
- DrugBank Accession Number
- DB13483
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 263.31
Monoisotopic: 263.082743825 - Chemical Formula
- C10H17NO5S
- Synonyms
- Etamsylate
- Ethamsylate
- External IDs
- E 141
- MD-141
Pharmacology
- Indication
Not Available
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Prophylaxis of Hemorrhage •••••••••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- ATC Codes
- B02BX01 — Etamsylate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzenesulfonic acids and derivatives. These are organic compounds containing a sulfonic acid or a derivative thereof that is linked to a benzene ring.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Benzenesulfonic acids and derivatives
- Direct Parent
- Benzenesulfonic acids and derivatives
- Alternative Parents
- Benzenesulfonyl compounds / 1-sulfo,2-unsubstituted aromatic compounds / Hydroquinones / 1-hydroxy-2-unsubstituted benzenoids / Sulfonyls / Organosulfonic acids / Dialkylamines / Organopnictogen compounds / Organooxygen compounds / Organic oxides show 1 more
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 1-sulfo,2-unsubstituted aromatic compound / Amine / Aromatic homomonocyclic compound / Arylsulfonic acid or derivatives / Benzenesulfonate / Benzenesulfonyl group / Hydrocarbon derivative / Hydroquinone / Organic nitrogen compound show 13 more
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 24YL531VOH
- CAS number
- 2624-44-4
- InChI Key
- HBGOLJKPSFNJSD-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H6O5S.C4H11N/c7-4-1-2-5(8)6(3-4)12(9,10)11;1-3-5-4-2/h1-3,7-8H,(H,9,10,11);5H,3-4H2,1-2H3
- IUPAC Name
- 2,5-dihydroxybenzene-1-sulfonic acid; diethylamine
- SMILES
- CCNCC.OC1=CC(=C(O)C=C1)S(O)(=O)=O
References
- General References
- External Links
- ChemSpider
- 16553
- 4112
- ChEBI
- 31563
- ChEMBL
- CHEMBL1514715
- Wikipedia
- Etamsylate
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Recruiting Supportive Care Blood Loss During Surgery / Ethamsylate Allergy / Misoprostol Allergy / Myoma / Oxytocin Allergy / Tranexamic Acid Allergy 1 1, 2 Completed Treatment Blood Loss During Surgery / Postoperative Hemorrhages 1 1, 2 Unknown Status Prevention Postpartum Haemorrhage (PPH) 1 Not Available Completed Treatment Blood Loss During Surgery / Postoperative Hemorrhages 1 Not Available Not Yet Recruiting Prevention Postpancreatectomy Hemorrhage 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intramuscular 250.000 mg Capsule Oral 500.000 mg Injection, solution Intramuscular; Intravenous 250 MG/2ML Solution Parenteral 250.000 mg Tablet Oral 250 MG Tablet Oral 500.000 mg Capsule, coated Oral 500 mg Tablet Oral 500 mg Injection Intramuscular; Intravenous 250 mg/2ml Tablet Oral Solution Intramuscular; Intravenous 250 mg - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 17.4 mg/mL ALOGPS logP -0.9 ALOGPS logP 1.2 Chemaxon logS -1 ALOGPS pKa (Strongest Acidic) -2.8 Chemaxon pKa (Strongest Basic) -6 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 94.83 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 40.64 m3·mol-1 Chemaxon Polarizability 15.98 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 139.5655365 predictedDarkChem Lite v0.1.0 [M-H]- 149.3538 predictedDeepCCS 1.0 (2019) [M+H]+ 141.4900365 predictedDarkChem Lite v0.1.0 [M+H]+ 151.71184 predictedDeepCCS 1.0 (2019) [M+Na]+ 139.5020365 predictedDarkChem Lite v0.1.0 [M+Na]+ 158.75383 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:42 / Updated at May 05, 2021 20:31