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Displaying results 6581 - 6590 of 10000 in total
  1. Drug

    Rimonabant

    go.drugbank.com/drugs/DB06155
    ApprovedWithdrawn

    This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression. … Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States.

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: ACOMPLIA ® COMPRIMIDOS RECUBIERTOS20 MG
  2. Target

    2-dehydro-3-deoxyphosphooctonate aldolase

    go.drugbank.com/bio_entities/BE0001394
    TargetShigella flexneri

    Polypeptides: 2-dehydro-3-deoxyphosphooctonate aldolaseSynonyms: Phospho-2-dehydro-3-deoxyoctonate aldolase, 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
  3. Target

    3-methyl-2-oxobutanoate hydroxymethyltransferase

    go.drugbank.com/bio_entities/BE0001822
    TargetNeisseria meningitidis serogroup B (strain MC58)

    Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

    Polypeptides: 3-methyl-2-oxobutanoate hydroxymethyltransferaseFunction: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
  4. Drug

    Anidulafungin

    go.drugbank.com/drugs/DB00362
    Approved

    There is preliminary evidence that it has a similar safety profile to caspofungin. … Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366.

    Products: FUNİDUL 100 MG İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ, 1 ADET, ERAXIS 100 MG INF. COZ. ICIN TOZ ICEREN FLAKON, 1 ADET VE COZUCU
  5. Drug

    Ociperlimab

    go.drugbank.com/drugs/DB18947
    Investigational

    Ociperlimab is under investigation in clinical trial NCT04866017 (A Study to Compare Ociperlimab Plus Tislelizumab Versus Durvalumab Following Concurrent Chemoradiotherapy (Ccrt) in Patients With Stage

    Synonyms: Immunoglobulin g1-kappa, anti-(homo sapiens tigit (t-cell immunoreceptor with ig domain and itim, v-set ig member 9, vsig9, v-set and transmembrane member 3, vstm3)), humanized monoclonal antibody (ociperlimab, Immunoglobulin g1, anti-(human receptor tigit) (human-mus musculus monoclonal bgb-a1217 .gamma.1-chain), disulfide with human-mus musculus monoclonal bgb-a1217 .kappa.-chain, dimer
  6. Drug

    Tiapride

    go.drugbank.com/drugs/DB13025
    Investigational

    Tiapride is a selective D2 and D3 dopamine receptor blocker in the brain.

    Categories: Dopamine D2 Receptor AntagonistsProducts: TIADAL 100 MG/2 ML AMPUL, 12 ADET, TIADAL 100 MG TABLET, 20 ADET
  7. Drug

    Upadacitinib

    go.drugbank.com/drugs/DB15091
    ApprovedInvestigational

    More recently, it has also been approved for the treatment of giant cell arteritis in adults and active polyarticular juvenile idiopathic arthritis in patients aged 2 years and older.[L10896] … Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsProducts: Rinvoq 45 mg Uzatılmış Salımlı Tablet, 28 ADET, Rinvoq 30 mg Uzatılmış Salımlı Tablet, 28 ADET
  8. Drug

    Eplerenone

    go.drugbank.com/drugs/DB00700
    ApprovedInvestigational

    Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone ...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ACENOL® 25 MG, INSPRA® 25 MG TABLETAS RECUBIERTAS
  9. Drug

    Sulthiame

    go.drugbank.com/drugs/DB08329
    Approved

    Categories: Heterocyclic Compounds, 1-RingProducts: Ospolot 200 mg Filmtabletten, Ospolot 50 mg Filmtabletten
  10. Drug

    Epoprostenol

    go.drugbank.com/drugs/DB01240
    ApprovedInvestigational

    A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue.

    Categories: Prostaglandins ISynonyms: Prostaglandin X, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid