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Benzatropine
go.drugbank.com/drugs/DB00245ApprovedInvestigational[A37914] Benztropine was developed by USL Pharma and officially approved by the FDA on 1996.[L5500] … It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970.
Products: Cogentin Inj 1mg/ml, Cogentin Tab 2mgTrandolapril
go.drugbank.com/drugs/DB00519ApprovedInvestigationalfor congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy. … Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment
Mixtures: TARKA 180MG/2MG, TARKA 180MG/2MGCategories: trandolapril and verapamil, ACE Inhibitors and Calcium Channel BlockersBrinzolamide
go.drugbank.com/drugs/DB01194Approved[A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination product with brimonidine tartrate. … [A2049,A2051] Brinzolamide was developed as a topical solution to the systemic side effects and [dorzolamide], the first-ever approved topical CA inhibitor with contrasting results and evidence.
Mixtures: SIMBRINZA 10mg/ml + 2mg/ml eye drops, suspension, AZARGA 10MG/ML+5MG/MLCategories: Antiglaucoma Preparations and Miotics, Genito Urinary System and Sex HormonesChlorhexidine
go.drugbank.com/drugs/DB00878ApprovedInvestigationalVet approvedWithdrawn[L11518,L11512,A190453] Chlorhexidine was developed in the UK by Imperial Chemical Industries in the early 1950s[A190474] and was introduced to the US in the 1970s. … [A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain.
Mixtures: easyangin Mentholgeschmack 5mg/1mg Lutschtabletten, QUIRUCIDAL NFCategories: Biguanides and Amidines, Alimentary Tract and MetabolismRizatriptan
go.drugbank.com/drugs/DB00953ApprovedInvestigationalRizatriptan is a second-generation triptan [A258918] and a selective 5-HT<sub>1B and 5-HT1D</sub> receptor agonist. … [L46018] Rizatriptan is available in oral tablets, orally disintegrating tablets (wafers), and oral film formulations.
Categories: Serotonin-1b and Serotonin-1d Receptor Agonist, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamineEplerenone
go.drugbank.com/drugs/DB00700ApprovedInvestigationalThe resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. … Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: INSPRA 25MG, EPLERENHEXAL 25MGDapagliflozin
go.drugbank.com/drugs/DB06292ApprovedInvestigational[A261596] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tubule of the nephron and causing glycosuria … [A261601] Dapagliflozin was originally approved by the FDA on Jan 08, 2014, to improve glycemic control in adults with type 2 diabetes in conjunction with diet and exercise.
Mixtures: XIGDUO XR TABLETS 10MG/500MG, XIGDUO XR TABLETS 10MG/1000MGCategories: Alimentary Tract and Metabolism, metformin and dapagliflozinDimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigational[L43752] Dimethyl fumarate is marketed under the brand name Tecfidera, and it was the third oral disease-modifying agent for multiple sclerosis approved by the FDA, following [fingolimod] and [teriflunomide … Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: (E)-But-2-enedioic acid dimethyl esterMavacamten
go.drugbank.com/drugs/DB14921ApprovedInvestigational[A248440] Mavacamten was also approved by Health Canada in October 2022 and by EMA in July 2023 for the same indication.[L44106,L47471] … It received initial US FDA approval in 2022, and it is one of the first myosin inhibitors to be used in humans.
Products: CAMZYOS® 10MG CAPSULAS DURAS, CAMZYOS® 2.5MG CAPSULAS DURAS DE LIBERACIÓN INMEDIATA.Camphor
go.drugbank.com/drugs/DB01744ApprovedInvestigationalWithdrawnThe FDA ruled that camphorated oil could not be marketed in the United States and that no product could contain a concentration higher than 11%. … It is used topically as a skin antipruritic and as an anti-infective agent.
Mixtures: Zam-Buk Ointment, Delsym No Mess Vapor Roll OnCategories: Basic Lotions and Liniments, Antipruritics and Local Anesthetics