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Temozolomide
go.drugbank.com/drugs/DB00853ApprovedInvestigationalIt is currently marketed under the trademark TEMODAR® by Merck.[L32033] … [A229853, A229888, A229923, L32033] Following initial hydrolysis, further reactions liberate a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesSynonyms: 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-oneGadopentetic acid
go.drugbank.com/drugs/DB00789ApprovedInvestigationalA complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. … (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Categories: Compounds used in a research, industrial, or household settingProducts: Magnevist 2 mmol/l - Injektionslösung, MAGNEVIST FLAKON, 5 MLLevofloxacin
go.drugbank.com/drugs/DB01137ApprovedInvestigationalLevofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin]. … [A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.[A190663]
Categories: Topoisomerase II Inhibitors, 4-QuinolonesSynonyms: (3S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid, (S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acidPentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigational[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for … [A226608] Pentoxifylline has been marketed in Europe since 1972; PTX extended-release tablets sold under the trade name TRENTAL by US Pharm Holdings were first approved by the FDA on Aug 30, 1984, but
Mixtures: Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesAmino acids
go.drugbank.com/drugs/DB09393InvestigationalMixture of amino acids ; used for parenteral nutrition in infants.
Mixtures: Ari S-Liner, Clinimix 3 % G-E - InfusionsbeutelProducts: AMINOACIDI ESSENZIALI E NON ESSENZIALI, AMINOSTERIL N-HEPAAntihemophilic factor (recombinant), PEGylated
go.drugbank.com/drugs/DB09329ApprovedInvestigationalPEGylation is the covalent attachment of a polyethylene glycol polymer, called PEG, to a drug or protein. … PEGylation decreases factor VIII clearance and allowing for an increased duration of drug circulation in the plasma [L1529].
Categories: Compounds used in a research, industrial, or household settingProducts: ADYNOVATE 500®IU / VIAL, ADYNOVATE®250IU/VIALDiclofenac
go.drugbank.com/drugs/DB00586ApprovedInvestigationalVet approvedDiclofenac, like other NSAIDs, is often used as first line therapy for acute and chronic pain and inflammation from a variety of causes. … [A180796] The addition of two chlorine groups in the ortho position of the phenyl ring locks the ring in maximal torsion which appears to be related to increased potency.
Mixtures: DermacinRx Lexitral PharmaPak II, AFTOJEL % 0,1 + %3 JEL (5 G)Categories: Cyclooxygenase-2 (COX-2) Inhibitors, P-glycoprotein inducersMetoprolol
go.drugbank.com/drugs/DB00264ApprovedInvestigational[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527] … Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.
Mixtures: METOPROLOL HCT S 100/12.5, METOPROLOL HCT S 100/12.5Categories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor AntagonistsDiamorphine
go.drugbank.com/drugs/DB01452ApprovedIllicitDiamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. … Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs.
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersSynonyms: O,O'-DiacetylmorphineFebrile Convulsions
go.drugbank.com/conditions/DBCOND0054185Synonyms: O/E - febrile convulsion, Febrile convulsion (& O/E)