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Apremilast
go.drugbank.com/drugs/DB05676ApprovedInvestigationalApremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. … [L7501] In July 2019, apremilast was granted a new FDA approval for the treatment of oral ulcers associated with Behcet's disease, an autoimmune condition that causes recurrent skin, blood vessel, and
Mixtures: OTEZLA 10 MG. 20 MG Y 30 MG, OTEZLA 10 MG. 20 MG Y 30 MGCategories: Cytochrome P-450 Substrates, P-glycoprotein substratesOglufanide
go.drugbank.com/drugs/DB05779InvestigationalOglufanide is a synthetic dipeptide immunomodulator in development for the treatment of chronic hepatitis C viral infection. … Oglufanide works as a regulator of the body's immune response, is being given by intranasal administration to patients with chronic hepatitis C viral infection.
Categories: Compounds used in a research, industrial, or household settingSynonyms: L-α-Glu-L-Trp, L-Glu-L-TrpEdonerpic
go.drugbank.com/drugs/DB05938InvestigationalEdonerpic is a neurotrophic agent intended for the treatment of Alzheimer's disease which is under phase I clinical trial.
Categories: Heterocyclic Compounds, 1-RingVarlitinib
go.drugbank.com/drugs/DB05944InvestigationalVarlitinib is an oral, selective, reversible, small molecule tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR. … Over-expression of ErbB-2 and EGFR receptors in tumors is predictive of poor prognosis in cancer patients.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingTranscrocetinate
go.drugbank.com/drugs/DB05974InvestigationalVitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma.
Categories: Compounds used in a research, industrial, or household settingSynonyms: 8,8'-diapo-ψ,ψ-carotenedioic acidAldoxorubicin
go.drugbank.com/drugs/DB06013InvestigationalAldoxorubicin, an antineoplastic agents, is an albumin-binding prodrug of doxorubicin.
Filanesib
go.drugbank.com/drugs/DB06040InvestigationalFilanesib is a potent Kinesin Spindle Protein (KSP) inhibitor that caused marked tumor regression in preclinical models of human solid tumors and human leukemias, often leading to durable responses.
Categories: Heterocyclic Compounds, 1-RingLumateperone
go.drugbank.com/drugs/DB06077ApprovedInvestigationalSchizophrenia is a complex mental illness and impacts approximately 1% of the population. … [A189093] Both characteristics lend to a more favourable adverse effect profile and ultimately safer drug.[A189093,L10908]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMianserin
go.drugbank.com/drugs/DB06148ApprovedWithdrawnA tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of [mirtazapine].
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 3-RingSynonyms: 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepineGarenoxacin
go.drugbank.com/drugs/DB06160ExperimentalGarenoxacin, a quinolone antibiotic, is being investigated for the treatment of gram-positive and gram-negative bacterial infections.
Categories: 4-Quinolones, Heterocyclic Compounds, 2-Ring