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Pentoxifylline
go.drugbank.com/drugs/DB00806ApprovedInvestigationalPentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties. … A branded product, PENTOXIL, marketed by Upsher-Smith Laboratories, and generic forms marketed by Valeant Pharmaceuticals and APOTEX have been available since the late 1990s.[L30300]
Mixtures: Betamethasone Dipropionate 0.05% / Minoxidil 5% / Niacinamide 2% / Pentoxifylline 0.5%Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingIndapamide
go.drugbank.com/drugs/DB00808ApprovedInvestigational[A204134,A204161] Indapamide is characterized by both a methylindoline and a sulfamoyl chlorobenzamide functional group, with the former being largely responsible for the molecule’s lipid solubility … [A204155] Treatment for hypertension should include a number of lifestyle changes (ie. reduced sodium intake) along with pharmacotherapy - it should be noted that treatment with several antihypertensive
Mixtures: PERINDO/IN RAT T 5/1.25, PERINDO/IN RAT T 5/1.25Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesRibavirin
go.drugbank.com/drugs/DB00811ApprovedInvestigationalThe dual therapy was administered for 48 weeks in patients with genotype 1, 4, 5, and 6, and 24 weeks in patients with genotype 2 and 3 [A19626]. … In HCV genotye 1/2/3/4/5/6 patients, ribavirin can be used in combination therapy involving [DB09102] and [DB08934], Eplusa ([DB08934], [DB11613]), Harvoni ([DB08934], [DB09027]), [DB06290] and [DB08934
Categories: Treatments for Hepatitis CSynonyms: 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamideMeloxicam
go.drugbank.com/drugs/DB00814ApprovedInvestigationalVet approvedIt is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201] … [A190189] With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations.
Mixtures: NURO-B, NURO-BCategories: COX-2 Inhibitors, Cytochrome P-450 SubstratesSodium lauryl sulfate
go.drugbank.com/drugs/DB00815ApprovedIt usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl.
Categories: Compounds used in a research, industrial, or household settingTadalafil
go.drugbank.com/drugs/DB00820ApprovedInvestigationalTadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy. … In contrast to other PDE5 inhibitors like [sildenafil], tadalafil has greater selectivity for PDE5 and a longer half-life which has made it a more suitable option for chronic once-daily dosing in the treatment
Mixtures: TADA PLUS 30/20 MG FILM KAPLI TABLET ,4 ADET, TADA PLUS 30/20 MG FILM KAPLI TABLET ,8 ADETCategories: 5-alpha Reductase Inhibitors, Cytochrome P-450 SubstratesPhensuximide
go.drugbank.com/drugs/DB00832ApprovedPhensuximide is a member of the succinimide class with anticonvulsant properties.
Categories: Heterocyclic Compounds, 1-RingProgabide
go.drugbank.com/drugs/DB00837ExperimentalProgabide is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. In clinical trials, progabide has been investigated for Pa...
Tolazamide
go.drugbank.com/drugs/DB00839ApprovedA sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesSynonyms: 1-(Hexahydro-1-azepinyl)-3-p-tolylsulfonylurea, 1-(Hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)ureaOxazepam
go.drugbank.com/drugs/DB00842ApprovedOxazepam is an intermediate-acting, 3-hydroxybenzodiazepine used in the treatment of alcohol withdrawal and anxiety disorders. … Oxazepam, like related 3-hydroxybenzodiazepine [lorazepam], is considered less susceptible to pharmacokinetic variability based on patient-specific factors (e.g. age, liver disease) - this feature is advantageous
Categories: Heterocyclic Compounds, 2-Ring