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Cefuroxime
go.drugbank.com/drugs/DB01112ApprovedInvestigationalBroad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Mixtures: TUGENS 250 MG IM ENJEKSIYON ICIN TOZ ICEREN FLAKON, 1 ADET, TUGENS 750 MG IM ENJEKSIYON ICIN TOZ ICEREN FLAKON, 1 ADETCategories: Heterocyclic Compounds, 2-RingPapaverine
go.drugbank.com/drugs/DB01113ApprovedInvestigationalIt is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. … The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Categories: Heterocyclic Compounds, 2-RingProducts: PAPAVERIN HIDROKLORUR 0.04 G/2 ML BIOSEL AMPUL, 10 ADET, PAPAVERIN HIDROKLORUR 0.05 G/2 ML BIOSEL AMPUL, 10 ADETAmiodarone
go.drugbank.com/drugs/DB01118ApprovedInvestigationalAmiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. … [A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation.
Categories: Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexSynonyms: 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran, 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuranGliclazide
go.drugbank.com/drugs/DB01120ApprovedInvestigationalSulfonylureas are associated with weight gain, though less so than insulin. … [A39546] On the other hand, based on the pharmacological efficacy, gliclazide is considered a second-generation sulfonylurea which presents a higher potency and a shorter half-life.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesSynonyms: 1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea, 1-(hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)ureaRabeprazole
go.drugbank.com/drugs/DB01129ApprovedInvestigationalRabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. … Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Categories: Cytochrome P-450 Substrates, 2-PyridinylmethylsulfinylbenzimidazolesProducts: Raberprazole Sodium D/r, PARIET ® TABLETAS DE 20 MGDesoxycorticosterone pivalate
go.drugbank.com/drugs/DB01134ExperimentalVet approvedDesoxycorticosterone pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. … Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInternational brands: Cortexone M, Percorten MDoxepin
go.drugbank.com/drugs/DB01142ApprovedInvestigational[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. … Doxepin is a psychotropic agent with antidepressant and anxiolytic properties.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PURDOX %5 KREM, 30 G, EXPAN® 50 MGBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigational[A178816] Bupropion is sometimes used as an add-on agent to first-line treatments of depression such as selective serotonin reuptake inhibitor (SSRI) medications when there is a treatment-failure or … Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective
Mixtures: Appbutamone-DCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesBretylium
go.drugbank.com/drugs/DB01158ApprovedThe primary mode of action for bretylium is thought to be inhibition of voltage-gated K(+) channels. … Recent evidence has shown that bretylium may also inhibit the Na,K-ATPase by binding to the extracellular K-site.
Mixtures: Bretylium Tosylate 0.4% and Dextrose 5% Inj, Bretylium Tosylate 0.2% and Dextrose 5% InjSynonyms: 2-bromo-N-ethyl-N,N-dimethylbenzenemethanaminium, N-ethyl-N,N-dimethyl-2-bromobenzenemethanaminiumTerazosin
go.drugbank.com/drugs/DB01162ApprovedInvestigationalTerazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label][A176831]. … Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate[A176837].
Mixtures: Hytrin-7 Tabs 1mg-7 Tabs 2mg-14 Tabs 5mg, Hytrin-7 Tabs 1mg-7 Tabs 2mg-14 Tabs 5mgCategories: P-glycoprotein inhibitors, Peripheral alpha-1 blockers