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Displaying results 691 - 700 of 10000 in total
  1. Target

    Galanin receptor type 2

    go.drugbank.com/bio_entities/BE0011498
    TargetHumans

    Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). … The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i))

    Polypeptides: Galanin receptor type 2Function: galanin receptor activity
  2. Target

    Sigma intracellular receptor 2

    go.drugbank.com/bio_entities/BE0015084
    TargetHumans

    Sigma-2 receptor implicated in the regulation of multiple cellular processes, including cholesterol biosynthesis and trafficking, membrane trafficking, autophagy, lipid membrane-associated protein trafficking

    Polypeptides: Sigma intracellular receptor 2Synonyms: Sigma2 receptor, Sigma-2 receptor
  3. Target

    Chemerin-like receptor 1

    go.drugbank.com/bio_entities/BE0019036
    TargetHumans

    Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1.

    Polypeptides: Chemerin-like receptor 1Synonyms: Chemokine-like receptor 1, G protein-coupled receptor DEZ
  4. Drug

    Asciminib

    go.drugbank.com/drugs/DB12597
    ApprovedInvestigational

    Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). … More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995] which serves as a driver of CML proliferation in most patients with the disease.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
  5. Drug

    Hydroxychloroquine

    go.drugbank.com/drugs/DB01611
    ApprovedInvestigational

    [L8072] A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.[A192546] … Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].

    Synonyms: 2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol, 7-chloro-4-(4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinolineCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  6. Drug

    Etozoline

    go.drugbank.com/drugs/DB08982
    Experimental

    Etozoline is a loop diuretic.

    Categories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Fluocinolone acetonide

    go.drugbank.com/drugs/DB00591
    ApprovedInvestigationalVet approved

    [T357] It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. … Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity.

    International brands: Cordes FMixtures: KS - Q, LASALAR-Y
  8. Drug

    Regorafenib

    go.drugbank.com/drugs/DB08896
    ApprovedInvestigational

    Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 201...

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
  9. Drug

    Abiprubart

    go.drugbank.com/drugs/DB19333
    Investigational

    Abiprubart is being evaluated for its efficacy and safety in participants with Sjögren's Disease in clinical trial NCT06531395

    Synonyms: Immunoglobulin G4-kappa, anti-[Homo sapiens CD40 (TNFRSF5, tumor necrosis factor receptor (TNFR) superfamily member 5, p50)], humanized monoclonal antibody, (115-212), hinge 1-12 S10>P (222) (213-224), CH2 L
  10. Target

    Endothelin receptor type B

    go.drugbank.com/bio_entities/BE0000043
    TargetHumans

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Endothelin receptor type BSynonyms: Endothelin receptor non-selective type