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Nicergoline
go.drugbank.com/drugs/DB00699ApprovedAn ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Synonyms: (8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridinecarboxylate (ester), 10-methoxy-1,6-dimethylergoline-8β-methanol 5-bromonicotinateCategories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsNaltrexone
go.drugbank.com/drugs/DB00704ApprovedInvestigationalVet approvedDerivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. … It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction.
Synonyms: N-Cyclopropylmethylnoroxymorphone, N-Cyclopropylmethyl-14-hydroxydihydromorphinoneCategories: Heterocyclic Compounds with 4 or More RingsTamsulosin
go.drugbank.com/drugs/DB00706ApprovedInvestigationalTamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common. … [Label] Other alpha-1 adrenoceptor antagonists developed in the 1980s were less selective and more likely to act on the smooth muscle of blood vessels, resulting in hypotension.
Synonyms: (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide, (R)-(−)-tamsulosinInternational brands: Harnal DSufentanil
go.drugbank.com/drugs/DB00708ApprovedInvestigational(AcelRx), was approved on November 2, 2018 [L4717]. … Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
Synonyms: 舒芬太尼, N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamideCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingIbandronate
go.drugbank.com/drugs/DB00710ApprovedInvestigationalIbandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid]. … [L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805]
Mixtures: IBONE D®, IBONE D 30000Products: BONVIVA® 3 MG/3 ML., BONDRONAT 2 MG/2 ML AMPUL, 5 ADETOxacillin
go.drugbank.com/drugs/DB00713ApprovedInvestigationalAn antibiotic similar to flucloxacillin used in resistant staphylococci infections.
Synonyms: (2S,5R,6R)-3,3-dimethyl-6-{[(5-methyl-3-phenylisoxazol-4-yl)carbonyl]amino}-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, (5-methyl-3-phenyl-4-isoxazolyl)penicillinInternational brands: Staficilin-NParoxetine
go.drugbank.com/drugs/DB00715ApprovedInvestigationalParoxetine is a selective serotonin reuptake inhibitor (SSRI) drug commonly known as Paxil. … Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.
Synonyms: (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine, (−)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidineCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesMethoxamine
go.drugbank.com/drugs/DB00723ApprovedInvestigationalWithdrawnAn alpha-adrenergic agonist that causes prolonged peripheral vasoconstriction. It has little if any direct effect on the central nervous system.
Categories: Adrenergic alpha-1 Receptor AgonistsHomatropine methylbromide
go.drugbank.com/drugs/DB00725ApprovedHomatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics.
Synonyms: 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide mandelate, 8-Methylhomatropinium bromideMixtures: Debiline H, BONESPAS® TABLETASNateglinide
go.drugbank.com/drugs/DB00731ApprovedApproximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. … It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates