Oxacillin is a penicillin antibiotic used to treat a number of susceptible bacterial infections. An antibiotic similar to flucloxacillin used in resistant staphylococci infections.
- Mechanism
- Curator reviewed
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor.
- Primary indication
- Used in the treatment of resistant staphylococci infections.Curator reviewed · 5 structured indications
- Formula / weight
- C19H19N3O5S · 401.436 g/mol (avg)
- First approval
- United States, 1976
- Also known as
- Oxazocillin
- Code names
- AB 1400 · BRL 1400 · P 12 · SQ 16423
Resolves to
Clinical / RWD
Structure
InChIKey
UWYHMGVUTGAWSP-JKIFEVAISA-NSMILES[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C1=C(C)ON=C1C1=CC=CC=C1)C(O)=OTransporters
What you can answer from here — as of September 30, 2026
10Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
2TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Oxacillin, and which of those have an active Phase 3 trial?
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