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Zidovudine
go.drugbank.com/drugs/DB00495ApprovedInvestigationalA dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. … Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
Mixtures: Zidovex L (Lamivudine 150mg and Zidovudine 300mg Tablets), ARROW LZ (Lamivudine 150mg and Zidovudine 300mg ) TabletsCategories: zidovudine and lamivudine, zidovudine, lamivudine and abacavirEplerenone
go.drugbank.com/drugs/DB00700ApprovedInvestigationalEplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative … The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: INSPRA 25MG, EPLERENHEXAL 25MGMethylcellulose
go.drugbank.com/drugs/DB11228ApprovedInvestigationalMethyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. … Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics.
Categories: Alimentary Tract and MetabolismProducts: Foster and Thrive Fiber Laxative 188, Rite Aid Fiber TherapyAbemaciclib
go.drugbank.com/drugs/DB12001ApprovedInvestigationalAbemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity … Abemaciclib has been used in trials studying the treatment of melanoma, lymphoma, neoplasm, solid tumor, and glioblastoma.
Categories: Antineoplastic and Immunomodulating AgentsProducts: VERZENIO FILM-COATED TABLET 100MG, Yulareb 100mg film-coated tabletsFish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126563Drug actionEPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.
Midostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalIt was approved on April 28, 2017 and has shown to increase the overall survival rate in patients with AML as an adjunct therapy along with chemotherapeutic agents. … It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hematopoietic tumors [A19108].
Categories: Antineoplastic and Immunomodulating AgentsProducts: Rydapt 25mg Soft Capsules, RYDAPT SOFT CAPSULE 25MGRiociguat
go.drugbank.com/drugs/DB08931ApprovedInvestigationalRiociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for … Riociguat is marketed under the brand Adempas® by Bayer HealthCare Pharmaceuticals. Treatment with riociguat costs USD $7,500 for 30 days of treatment.
Products: Adempas 1mg film-coated tablet, Adempas 2.5mg film-coated tabletNaloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approved[L33729,L33739] Naloxone IM injections are commonly available in the form of "kits", which is ideal for making overdose treatment accessible and readily available for administration by minimally trained … Frequently also carried by medical and emergency personnel and at events known to be associated with heavy drug use like music festivals, naloxone kits are considered a key component of harm reduction
Mixtures: TARGIN 20MG/10MG, TARGIN 20MG/10MGCategories: Alimentary Tract and Metabolism, tilidine and naloxoneEstazolam
go.drugbank.com/drugs/DB01215ApprovedIllicitInvestigationalA benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.
Categories: Hypnotics and Sedatives, Benzodiazepine hypnotics and sedativesProducts: Prosom Tab 1mg, Prosom Tab 2mgCefotaxime
go.drugbank.com/drugs/DB00493ApprovedInvestigationalLike other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. … In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Products: Cefotaxime and Dextrose, Claforan Inj 1gm/add-vantage Vial