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Pizotifen
go.drugbank.com/drugs/DB06153ApprovedPizotifen belongs to the class of antamines and is related to [cyproheptadine].[A32532] It is a potent serotonin and tryptamine antagonist that has been used for migraine prevention for many years. … Some patients receiving pizotifen treatment developed tolerance with the prolonged use of the drug [L2292].
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeVaricella zoster vaccine (recombinant)
go.drugbank.com/drugs/DB13924ApprovedInvestigationalShingrix also contains an adjuvant system, AS01B, which is intended to enhance the immunological response to the vaccine leading to longer lasting and greater immunogenicity to the herpes zoster virus … Immune exposure to gE protein stimulates the development of anti-gE antibodies, and therefore adaptive immunity to VZV.
Synonyms: gE recombinant Varicella zoster virus (VZV) glycoprotein E, gE: Recombinant Varicella Zoster Virus (VZV) glycoprotein ETeplizumab
go.drugbank.com/drugs/DB06606ApprovedInvestigational[A241480,A241500] Targeting T cells can be achieved through antibodies against the T cell receptor (TCR) component CD3. … [A241480] On November 2022, teplizumab was approved by the FDA as the first drug that can delay the onset of type 1 diabetes.
Nabilone
go.drugbank.com/drugs/DB00486ApprovedInvestigationalNabilone is a racemate consisting of the (S,S) and the (R,R) isomers. … Nabilone is approved by the FDA for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments [FDA
Andexanet alfa
go.drugbank.com/drugs/DB14562ApprovedThe amino acid residue modification from serine to alanine in the binding site of the catalytic domain allows more effective binding to FXa inhibitors and deters the andexanet alfa from converting prothrombin … to thrombin [A35558].
Haloperidol
go.drugbank.com/drugs/DB00502ApprovedInvestigationalbe caused by a hyperdopaminergic state within the limbic system of the brain. … (mainly D2), particularly within the mesolimbic and mesocortical systems of the brain.
Products: HALDOL JANSSEN DECANOAT DE, HALOPERIDOL TABLETAS DE 10 MGAnethole trithione
go.drugbank.com/drugs/DB13853ApprovedAnethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia [A27165, A32618, A32620, A32621], to demonstrating an ability to … Unfortunately, many of the specific mechanisms of action to these activities have yet to be formally elucidated, which means that while studies are ongoing, ATT itself is not necessarily formally indicated
Gadodiamide
go.drugbank.com/drugs/DB00225ApprovedInvestigational[A263096] Approved by the FDA in 1993, gadodiamide is the first non-ionic GBCA to be used. … [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents.
Technetium Tc-99m exametazime
go.drugbank.com/drugs/DB09163ApprovedIt can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. … Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases.
Synonyms: (99m)Tc HMPAO, (99m)Tc HM-PAOGalantamine
go.drugbank.com/drugs/DB00674ApprovedInvestigational[A182993] The drug was approved by the FDA in 2001 for the treatment of mild to moderate dementia of the Alzheimer's type. … Galantamine works to block the enzyme responsible for the breakdown of acetylcholine in the synaptic cleft, thereby enhancing cholinergic neuron function and signalling.
Products: REMINYL ®ER CAPSULAS DE 8 MG, REMINYL ® ER CAPSULAS DE 16 MG