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Displaying results 741 - 750 of 10000 in total
  1. Drug

    Esomeprazole

    go.drugbank.com/drugs/DB00736
    ApprovedInvestigational

    Esomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the (H+, K+)-ATPase enzyme … [A177577, A177580] Due to their good safety profile and as several PPIs are available over the counter without a prescription, their current use in North America is widespread.

    Mixtures: RUMONAL® PRO 15, RUMONAL® PRO 7.5Categories: Antiinflammatory and Antirheumatic Products, Non-Steroids, Cytochrome P-450 Substrates
  2. Drug

    Tiotropium

    go.drugbank.com/drugs/DB01409
    ApprovedInvestigational

    [A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation. … Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.

    Mixtures: SPIOLTO®RESPIMAT®, SPIOLTO®RESPIMAT®Categories: Agents to Treat Airway Disease, Cytochrome P-450 Substrates
  3. Drug

    Azathioprine

    go.drugbank.com/drugs/DB00993
    ApprovedInvestigational

    Azathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic … [A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.

    Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
  4. Drug

    Eucalyptus oil

    go.drugbank.com/drugs/DB11114
    Approved

    Eucalyptus oil can be applied directly to the skin for pain and swelling of respiratory tract mucous membranes, joint pain, genital herpes, and nasal stuffiness. … It is shown to be effective in reducing pain, swelling, and inflammation via its modulatory effect on the immune response.

    Mixtures: Zam-Buk Ointment, NORAVER U
  5. Drug

    Bromhexine

    go.drugbank.com/drugs/DB09019
    ApprovedInvestigational

    It was introduced into the market in 1963, and is widely available as an over-the-counter drug in many countries. … [A233240] Recently, bromhexine and its metabolite [ambroxol] have garnered interest for the potential prevention and treatment of COVID-19 due to their interactions with cell receptors in the lungs.

    Mixtures: GLICERTOX N F, TO-FLEM (GUAYACOLATO+BROMHEXINA)Synonyms: N-cyclohexyl-N-methyl-(2-amino-3,5-dibrombenzyl)amine, 3,5-dibromo-N(alpha)-cyclohexyl-N(alpha)-methyltoluene-alpha-2-diamine
  6. Drug

    Metoclopramide

    go.drugbank.com/drugs/DB01233
    ApprovedInvestigational

    It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922] … It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.

    Mixtures: CLIFAR® GOTAS, PLASIL®ENZIMATICOCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substrates
  7. Drug

    CTX110

    go.drugbank.com/drugs/DB18626
    Investigational

    CTX110 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting CD19 antigen.

    Synonyms: allogeneic CRISPR/Cas9-mediated genetically modified CAR T cells targeting CD19 antigen
  8. Indication

    Hypophosphatemic Rickets

    go.drugbank.com/conditions/DBCOND0037223
    Drugs: Alfacalcidol
    Synonyms: HPDR I - Hypophosphatemic vitamin D-resistant rickets, HPDR I - Hypophosphataemic vitamin D-resistant rickets
  9. Indication

    Neurofibromatosis Type 1

    go.drugbank.com/conditions/DBCOND0029664
    Drugs: Mirdametinib · Selumetinib
    Synonyms: Neurofibromatosis I, Neurofibromatosis Type I
  10. Drug

    Meradimate

    go.drugbank.com/drugs/DB11096
    Approved

    [T200] It is currently required to be named as meradimate in all FDA approved OTC products. Meradimate is approved by the FDA and Health Canada to be used as an ingredient in sunblocking products. … Meradimate, before known as menthyl anthranilate, is used in a maximal concentration of 5% in different products as a UV filter.

    Mixtures: Body Armor Sun 'n Bug Block, Nutriance Uv Control Skin Protection Creme SPF 8Synonyms: Menthyl-O-aminobenzoate