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Clopidogrel
go.drugbank.com/drugs/DB00758ApprovedInvestigational,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesAminophylline
go.drugbank.com/drugs/DB01223ApprovedInvestigationalAminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesTicagrelor
go.drugbank.com/drugs/DB08816ApprovedInvestigationalTicagrelor, or AZD6140, was first described in the literature in 2003. Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism. Unlike clopidogrel, ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilin...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTheophylline
go.drugbank.com/drugs/DB00277ApprovedInvestigationalA methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine recep...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesLosartan
go.drugbank.com/drugs/DB00678ApprovedInvestigationalLosartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associate...
Mixtures: LORZAAR PL FORTE100/12.5MGCategories: P-glycoprotein inhibitors, P-glycoprotein substratesTiclopidine
go.drugbank.com/drugs/DB00208ApprovedTiclopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlo...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsPeginterferon alfa-2b
go.drugbank.com/drugs/DB00022ApprovedInvestigationalPeginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus ...
Categories: Cytochrome P-450 CYP2C9 Inducers, Cytochrome P-450 Enzyme InducersAldesleukin
go.drugbank.com/drugs/DB00041ApprovedInvestigationalAldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 ge...
Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP3A InhibitorsSomatotropin
go.drugbank.com/drugs/DB00052ApprovedInvestigationalHuman growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland. Growth hormone plays an essential role in growth regulation during c...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InducersProducts: Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 10Gemtuzumab ozogamicin
go.drugbank.com/drugs/DB00056ApprovedInvestigationalGemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzuma...