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1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
go.drugbank.com/drugs/DB03477ExperimentalSynonyms: 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole5-Mercaptoethanol-2-decenoyl-coenzyme A
go.drugbank.com/drugs/DB03698ExperimentalSynonyms: 5-Mercaptoethanol-2-decenoyl-coenzyme A7-methyl-7,8-dihydroguanosine-5'-diphosphate
go.drugbank.com/drugs/DB01960ExperimentalSynonyms: 7-methyl-7,8-dihydroguanosine-5'-diphosphateRitlecitinib
go.drugbank.com/drugs/DB14924ApprovedInvestigationalIn June 2023, it was approved by the FDA for the treatment of severe alopecia areata in adults and adolescents 12 years and older.[L47092,L47127] It was further approved by the EMA in September 2023. … This makes ritlecitinib a highly selective and irreversible JAK3 inhibitor.
Categories: Heterocyclic Compounds, 1-Ring, Antineoplastic and Immunomodulating AgentsSynonyms: 2-propen-1-one, 1-((2S,5R)-2-methyl-5-(7H-pyrrolo(2,3-D)pyrimidin-4-ylamino)-1-piperidinyl)-Tradipitant
go.drugbank.com/drugs/DB12580ApprovedInvestigationalTradipitant is a selective, high-affinity antagonist at human substance P/neurokinin-1 (NK-1) receptors. … [L54903] NK-1 receptors are expressed in the brainstem and nucleus tractus solitarius, which receives emetogenic signals from various stimuli including dizziness and vertigo.
Categories: Heterocyclic Compounds, 1-Ring, Substance P/Neurokinin-1 Receptor AntagonistSynonyms: (2-(1-(3,5-BIS(TRIFLUOROMETHYL)BENZYL)-5-PYRIDIN-4-YL-1H-1,2,3-TRIAZOL-4-YL)PYRIDIN-3-YL)(2-CHLOROPHENYL)METHANONE, METHANONE, (2-(1-((3,5-BIS(TRIFLUOROMETHYL)PHENYL)METHYL)-5-(4-PYRIDINYL)-1H-1,2,3-TRIAZOL-4-YL)-3-PYRIDINYL)(2-CHLOROPHENYL)-Furazolidone
go.drugbank.com/drugs/DB00614InvestigationalVet approvedA nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase.
Categories: Heterocyclic Compounds, 1-Ring, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesSynonyms: 3-(5'-Nitrofurfuralamino)-2-oxazolidone, 3-[(5-Nitrofurylidene)amino]-2-oxazolidoneValoctocogene roxaparvovec
go.drugbank.com/drugs/DB15561ApprovedInvestigationalWithdrawnValoctocogene roxaparvovec is an adeno-associated virus serotype 5 (AAV5) based gene therapy vector that expresses the B-domain deleted SQ form of human coagulation factor VIII (hFVIII-SQ). … [L43282] The expression of hFVIII-SQ is driven by a liver-specific promoter, which enables hepatocytes to produce factor VIII protein and increase the levels of active factor VIII in blood.
Categories: Cellular and Gene Therapy, Blood and Blood Forming OrgansSynonyms: DNA (synthetic adeno-associated virus 5 vector BMN 270 human blood-coagulation factor VIII SQ variant-specifying)Ribavirin monophosphate
go.drugbank.com/drugs/DB14663ExperimentalSynonyms: Virazole 5'-phosphate, Ribavirin 5'-monophosphateCategories: Nucleic Acids, Nucleotides, and Nucleosides(6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
go.drugbank.com/drugs/DB07604ExperimentalSynonyms: (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONESparfloxacin
go.drugbank.com/drugs/DB01208ApprovedWithdrawnDNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. … Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase.
Categories: 4-Quinolones, P-glycoprotein substratesSynonyms: cis-5-Amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid