This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Ribavirin monophosphate
- DrugBank Accession Number
- DB14663
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Ribavirin monophosphate (DB14663)
- Weight
- Average: 324.1846
Monoisotopic: 324.047099924 - Chemical Formula
- C8H13N4O8P
- Synonyms
- Ribavirin 5'-monophosphate
- Virazole 5'-phosphate
- External IDs
- NSC-274937
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as triazole ribonucleosides and ribonucleotides. These are nucleoside derivatives containing a ribose (or deoxyribose) moiety which is N-glycosylated to a triazole. Nucleotides have a phosphate group linked to the C5 carbon of the ribose (or deoxyribose) moiety.
- Kingdom
- Organic compounds
- Super Class
- Nucleosides, nucleotides, and analogues
- Class
- Triazole ribonucleosides and ribonucleotides
- Sub Class
- Not Available
- Direct Parent
- Triazole ribonucleosides and ribonucleotides
- Alternative Parents
- Pentose phosphates / Glycosylamines / Monosaccharide phosphates / 2-heteroaryl carboxamides / Monoalkyl phosphates / Triazoles / Tetrahydrofurans / Heteroaromatic compounds / Primary carboxylic acid amides / Secondary alcohols show 7 more
- Substituents
- 1,2,4-triazole / 1,2-diol / 2-heteroaryl carboxamide / Alcohol / Alkyl phosphate / Aromatic heteromonocyclic compound / Azacycle / Azole / Carboxamide group / Carboxylic acid derivative show 25 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- O9FVV27P11
- CAS number
- 40925-28-8
- InChI Key
- SDWIOXKHTFOULX-AFCXAGJDSA-N
- InChI
- InChI=1S/C8H13N4O8P/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(20-8)1-19-21(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H2,16,17,18)/t3-,4-,5-,8-/m1/s1
- IUPAC Name
- {[(2R,3S,4R,5R)-5-(3-carbamoyl-1H-1,2,4-triazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
- SMILES
- NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
References
- General References
- Not Available
- External Links
- ChemSpider
- 90600
- ChEMBL
- CHEMBL1235764
- ZINC
- ZINC000012402859
- PDBe Ligand
- RVP
- PDB Entries
- 1me7 / 1me8 / 1nf7 / 1r6a / 7dfh
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 3.34 mg/mL ALOGPS logP -2.7 ALOGPS logP -2.9 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 1.23 Chemaxon pKa (Strongest Basic) -1.2 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 190.25 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 75.45 m3·mol-1 Chemaxon Polarizability 26.39 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at September 03, 2018 14:37 / Updated at June 12, 2020 16:53