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Triclabendazole
go.drugbank.com/drugs/DB12245ApprovedInvestigational[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common liver fluke” or “the sheep liver fluke” or by _Fasciola … Triclabendazole was previously used in the treatment of fascioliasis in livestock, but is now approved for human use.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A1 SubstratesMoxaverine
go.drugbank.com/drugs/DB12251InvestigationalMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
Categories: Heterocyclic Compounds, 2-RingPlatinum
go.drugbank.com/drugs/DB12257InvestigationalPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and
Categories: Compounds used in a research, industrial, or household settingLosmapimod
go.drugbank.com/drugs/DB12270InvestigationalLosmapimod has been investigated for the prevention of Chronic Obstructive Pulmonary Disease.
Categories: Heterocyclic Compounds, 1-RingORE-1001
go.drugbank.com/drugs/DB12271InvestigationalIt is an ACE2 inhibitor.
Categories: Heterocyclic Compounds, 1-RingSeviteronel
go.drugbank.com/drugs/DB12275InvestigationalSeviteronel has been used in trials studying the treatment of CRPC, Prostate Cancer, and Castration-resistant Prostate Cancer.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 Enzyme InhibitorsLuspatercept
go.drugbank.com/drugs/DB12281ApprovedInvestigationalLuspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1. … [A187835] Luspatercept's novel mechanism of action, then, is uniquely suited for the treatment of conditions in which late-stage erythropoiesis is defective, such as beta thalassemia and other myelodysplastic
Products: REBLOZYL®LY-2608204
go.drugbank.com/drugs/DB12284InvestigationalLY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
Categories: Heterocyclic Compounds, 1-RingVerubecestat
go.drugbank.com/drugs/DB12285InvestigationalVerubecestat is Merck’s investigational oral β-site amyloid precursor protein cleaving enzyme (BACE1 or β secretase) inhibitor. … In the study, administration of Verubecestat at doses of 12, 40 and 60 mg resulted in a dose-dependent and sustained reduction in the levels of Ab40, a measure of BACE1 activity, in CSF from baseline of
Categories: Heterocyclic Compounds, 1-RingSimendan
go.drugbank.com/drugs/DB12286ExperimentalCategories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 Inhibitors