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Verubecestat
go.drugbank.com/drugs/DB12285InvestigationalVerubecestat is Merck’s investigational oral β-site amyloid precursor protein cleaving enzyme (BACE1 or β secretase) inhibitor. … In the study, administration of Verubecestat at doses of 12, 40 and 60 mg resulted in a dose-dependent and sustained reduction in the levels of Ab40, a measure of BACE1 activity, in CSF from baseline of
Categories: Heterocyclic Compounds, 1-RingSimendan
go.drugbank.com/drugs/DB12286ExperimentalCategories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 InhibitorsPiromelatine
go.drugbank.com/drugs/DB12288InvestigationalPiromelatine has been used in trials studying the treatment of Alzheimer's Disease.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingPuerarin
go.drugbank.com/drugs/DB12290InvestigationalPuerarin has been investigated for the treatment of Alcohol Abuse.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingNefopam
go.drugbank.com/drugs/DB12293ApprovedInvestigationalWithdrawnNefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering. Nefopam has been investigated for the prevention of Kidney Transplantation.
Categories: Heterocyclic Compounds, 1-RingProducts: KATAMOX® SOLUCIÓN INYECTABLEEvodenoson
go.drugbank.com/drugs/DB12295InvestigationalEvodenoson has been used in trials studying the treatment of Open-angle Glaucoma and Ocular Hypertension.
Categories: Heterocyclic Compounds, 1-RingGLPG-0187
go.drugbank.com/drugs/DB12297InvestigationalGLPG0187 has been used in trials studying the treatment of Solid Tumors.
Categories: Heterocyclic Compounds, 2-RingCipargamin
go.drugbank.com/drugs/DB12306InvestigationalCipargamin has been used in trials studying the treatment of Malaria, Cure Rate, and Plasmodium Falciparum Malaria.
Categories: Heterocyclic Compounds, 2-RingForetinib
go.drugbank.com/drugs/DB12307InvestigationalForetinib is an orally available small molecule compound designed to target multiple RTKs implicated in the development, progression and spread of cancer.
Categories: Heterocyclic Compounds, 2-RingIdasanutlin
go.drugbank.com/drugs/DB12325InvestigationalIdasanutlin has been used in trials studying the treatment of Neoplasms, Non-Hodgkin's Lymphoma, Leukemia, Myeloid, Acute, Recurrent Plasma Cell Myeloma, and Neoplasms, Leukemia, Acute Myeloid Leukemia.
Synonyms: BENZOIC ACID, 4-((((2R,3S,4R,5S)-3-(3-CHLORO-2-FLUOROPHENYL)-4-(4-CHLORO-2-FLUOROPHENYL)-4-CYANO-5-(2,2-DIMETHYLPROPYL)-2-PYRROLIDINYL)CARBONYL)AMINO)-3-METHOXY-Categories: Heterocyclic Compounds, 1-Ring, Proto-Oncogene Proteins c-mdm2, antagonists & inhibitors